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Protein
Submitted name:

Fibroblast growth factor receptor 2

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-190377 FGFR2b ligand binding and activation
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Fibroblast growth factor receptor 2Imported
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95523 Fgfr2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiD6RJK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000030849
ExpressionAtlasiD6RJK5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6RJK5
SMRiD6RJK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 144Ig-likeInterPro annotationAdd BLAST87
Domaini173 – 266Ig-likeInterPro annotationAdd BLAST94

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000186010

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

D6RJK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT
60 70 80 90 100
TLEPEEPPTK YQISQPEAYV VAPGESLELQ CMLKDAAVIS WTKDGVHLGP
110 120 130 140 150
NNRTVLIGEY LQIKGATPRD SGLYACTAAR TVDSETWYFM VNVTDAISSG
160 170 180 190 200
DDEDDTDSSE DVVSENRSNQ RAPYWTNTEK MEKRLHAVPA ANTVKFRCPA
210 220 230 240 250
GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV VPSDKGNYTC
260 270 280 290 300
LVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY
310 320 330
SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKRL
Length:334
Mass (Da):37,162
Last modified:July 13, 2010 - v1
Checksum:i2FB53F038D72F639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA No translation available.
AC110885 Genomic DNA No translation available.
AC111058 Genomic DNA No translation available.
AC115697 Genomic DNA No translation available.
AC122258 Genomic DNA No translation available.
AC145294 Genomic DNA No translation available.
AC149596 Genomic DNA No translation available.
AC157606 Genomic DNA No translation available.
AC158113 Genomic DNA No translation available.
AC175034 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000153166; ENSMUSP00000120100; ENSMUSG00000030849
UCSCiuc009jzz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiD6RJK5_MOUSE
AccessioniPrimary (citable) accession number: D6RJK5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health