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Protein

Histone-lysine N-methyltransferase

Gene

SETD7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:SETD7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30412. SETD7.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145391.

PTM / Processingi

Proteomic databases

MaxQBiD6RJA0.
PaxDbiD6RJA0.
PeptideAtlasiD6RJA0.
PRIDEiD6RJA0.

Expressioni

Gene expression databases

BgeeiENSG00000145391.
ExpressionAtlasiD6RJA0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD6RJA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni226 – 228S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1079. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00390000004827.
HOGENOMiHOG000074731.

Family and domain databases

InterProiView protein in InterPro
IPR017155. Hist-Lys_N-MeTrfase_SET.
IPR003409. MORN.
PfamiView protein in Pfam
PF02493. MORN. 4 hits.
PROSITEiView protein in PROSITE
PS51577. SAM_MT43_SET7. 1 hit.

Sequencei

Sequence statusi: Complete.

D6RJA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK
60 70 80 90 100
FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT
110 120 130 140 150
DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD
160 170 180 190 200
ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC
210 220 230 240 250
ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI
260 270 280 290 300
THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT
310 320 330 340 350
PNCIYDIGQK NHLGTCKRSR FGAPLPKIPH LDQAPWVEHR KAGIPLYSAA
360
QGLMLIMMFV SN
Length:362
Mass (Da):40,127
Last modified:July 13, 2010 - v1
Checksum:i4A7D03C51F20CAE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112236 Genomic DNA. No translation available.
AC114743 Genomic DNA. No translation available.
RefSeqiNP_001293128.1. NM_001306199.1.
UniGeneiHs.480792.

Genome annotation databases

EnsembliENST00000506866; ENSP00000427300; ENSG00000145391.
GeneIDi80854.
UCSCiuc062zss.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD6RJA0_HUMAN
AccessioniPrimary (citable) accession number: D6RJA0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 5, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported