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Protein
Submitted name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseImported
Gene namesi
Name:HMGCRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:5006. HMGCR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 37HelicalSequence analysisAdd BLAST18
Transmembranei57 – 78HelicalSequence analysisAdd BLAST22
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113161.

PTM / Processingi

Proteomic databases

MaxQBiD6RIW0.
PaxDbiD6RIW0.
PeptideAtlasiD6RIW0.

Expressioni

Gene expression databases

BgeeiENSG00000113161.
ExpressionAtlasiD6RIW0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287936.

Structurei

3D structure databases

ProteinModelPortaliD6RIW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 111SSD (sterol-sensing)InterPro annotationAdd BLAST51

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2480. Eukaryota.
COG1257. LUCA.
GeneTreeiENSGT00840000129910.
HOGENOMiHOG000183489.

Family and domain databases

InterProiIPR002202. HMG_CoA_Rdtase.
IPR000731. SSD.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D6RIW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC
60 70 80 90 100
PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI
110
FSSFVFSTVV I
Length:111
Mass (Da):12,721
Last modified:July 13, 2010 - v1
Checksum:i0A3C08FEEEF1BE2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei111Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000507942; ENSP00000427340; ENSG00000113161.
UCSCiuc063epq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RIW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000287936.

Proteomic databases

MaxQBiD6RIW0.
PaxDbiD6RIW0.
PeptideAtlasiD6RIW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000507942; ENSP00000427340; ENSG00000113161.
UCSCiuc063epq.1. human.

Organism-specific databases

HGNCiHGNC:5006. HMGCR.
OpenTargetsiENSG00000113161.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2480. Eukaryota.
COG1257. LUCA.
GeneTreeiENSGT00840000129910.
HOGENOMiHOG000183489.

Miscellaneous databases

ChiTaRSiHMGCR. human.

Gene expression databases

BgeeiENSG00000113161.
ExpressionAtlasiD6RIW0. baseline and differential.

Family and domain databases

InterProiIPR002202. HMG_CoA_Rdtase.
IPR000731. SSD.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6RIW0_HUMAN
AccessioniPrimary (citable) accession number: D6RIW0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.