Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D6RIW0

- D6RIW0_HUMAN

UniProt

D6RIW0 - D6RIW0_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: Ensembl
  3. hydroxymethylglutaryl-CoA reductase activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. cholesterol biosynthetic process Source: Ensembl
  3. coenzyme A metabolic process Source: InterPro
  4. myoblast differentiation Source: Ensembl
  5. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  6. negative regulation of MAP kinase activity Source: Ensembl
  7. negative regulation of striated muscle cell apoptotic process Source: Ensembl
  8. negative regulation of vasodilation Source: Ensembl
  9. negative regulation of wound healing Source: Ensembl
  10. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  12. positive regulation of skeletal muscle tissue development Source: Ensembl
  13. positive regulation of smooth muscle cell proliferation Source: Ensembl
  14. positive regulation of stress-activated MAPK cascade Source: Ensembl
  15. response to ethanol Source: Ensembl
  16. response to nutrient Source: Ensembl
  17. ubiquinone metabolic process Source: Ensembl
  18. visual learning Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseImported
Gene namesi
Name:HMGCRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:5006. HMGCR.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. intracellular membrane-bounded organelle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD6RIW0.
ExpressionAtlasiD6RIW0. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliD6RIW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119321.
HOGENOMiHOG000183489.

Family and domain databases

InterProiIPR002202. HMG_CoA_Rdtase.
IPR000731. SSD.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D6RIW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC
60 70 80 90 100
PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI
110
FSSFVFSTVV I
Length:111
Mass (Da):12,721
Last modified:July 13, 2010 - v1
Checksum:i0A3C08FEEEF1BE2E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei111 – 1111Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000507942; ENSP00000427340; ENSG00000113161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali D6RIW0.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi D6RIW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000507942 ; ENSP00000427340 ; ENSG00000113161 .

Organism-specific databases

HGNCi HGNC:5006. HMGCR.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119321.
HOGENOMi HOG000183489.

Miscellaneous databases

ChiTaRSi HMGCR. human.
NextBioi 35494930.

Gene expression databases

Bgeei D6RIW0.
ExpressionAtlasi D6RIW0. baseline and differential.

Family and domain databases

InterProi IPR002202. HMG_CoA_Rdtase.
IPR000731. SSD.
[Graphical view ]
PANTHERi PTHR10572. PTHR10572. 1 hit.
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiD6RIW0_HUMAN
AccessioniPrimary (citable) accession number: D6RIW0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3