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D6RIW0 (D6RIW0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:HMGCR Ensembl ENSP00000427340
OrganismHomo sapiens (Human) [Reference proteome] Ensembl ENSP00000427340
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length111 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000427340

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from electronic annotation. Source: Ensembl

cholesterol biosynthetic process

Inferred from electronic annotation. Source: Ensembl

coenzyme A metabolic process

Inferred from electronic annotation. Source: InterPro

embryo development

Inferred from electronic annotation. Source: Ensembl

isoprenoid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

myoblast differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of insulin secretion involved in cellular response to glucose stimulus

Inferred from electronic annotation. Source: Ensembl

negative regulation of striated muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

negative regulation of wound healing

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of skeletal muscle tissue development

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of stress-activated MAPK cascade

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

ubiquinone metabolic process

Inferred from electronic annotation. Source: Ensembl

visual learning

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: InterPro

intracellular membrane-bounded organelle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Inferred from electronic annotation. Source: Ensembl

hydroxymethylglutaryl-CoA reductase activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue1111 Ensembl ENSP00000427340

Sequences

Sequence LengthMass (Da)Tools
D6RIW0 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 0A3C08FEEEF1BE2E

FASTA11112,721
        10         20         30         40         50         60 
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS 

        70         80         90        100        110 
DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV I 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC008897 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalD6RIW0.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBD6RIW0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000507942; ENSP00000427340; ENSG00000113161.

Organism-specific databases

HGNCHGNC:5006. HMGCR.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000183489.

Gene expression databases

ArrayExpressD6RIW0.
BgeeD6RIW0.

Family and domain databases

InterProIPR002202. HMG_CoA_Rdtase.
IPR000731. SSD.
[Graphical view]
PANTHERPTHR10572. PTHR10572. 1 hit.
PROSITEPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHmgcr. human.
NextBio35494930.

Entry information

Entry nameD6RIW0_HUMAN
AccessionPrimary (citable) accession number: D6RIW0
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.