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D6RIW0

- D6RIW0_HUMAN

UniProt

D6RIW0 - D6RIW0_HUMAN

Protein
Submitted name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: Ensembl
    3. hydroxymethylglutaryl-CoA reductase activity Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. cholesterol biosynthetic process Source: Ensembl
    3. coenzyme A metabolic process Source: InterPro
    4. embryo development Source: Ensembl
    5. isoprenoid biosynthetic process Source: Ensembl
    6. myoblast differentiation Source: Ensembl
    7. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
    8. negative regulation of MAP kinase activity Source: Ensembl
    9. negative regulation of striated muscle cell apoptotic process Source: Ensembl
    10. negative regulation of vasodilation Source: Ensembl
    11. negative regulation of wound healing Source: Ensembl
    12. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
    13. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    14. positive regulation of skeletal muscle tissue development Source: Ensembl
    15. positive regulation of smooth muscle cell proliferation Source: Ensembl
    16. positive regulation of stress-activated MAPK cascade Source: Ensembl
    17. response to ethanol Source: Ensembl
    18. response to nutrient Source: Ensembl
    19. ubiquinone metabolic process Source: Ensembl
    20. visual learning Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    3-hydroxy-3-methylglutaryl-coenzyme A reductaseImported
    Gene namesi
    Name:HMGCRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:5006. HMGCR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro
    2. intracellular membrane-bounded organelle Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiD6RIW0.
    BgeeiD6RIW0.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliD6RIW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000183489.

    Family and domain databases

    InterProiIPR002202. HMG_CoA_Rdtase.
    IPR000731. SSD.
    [Graphical view]
    PANTHERiPTHR10572. PTHR10572. 1 hit.
    PROSITEiPS50156. SSD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D6RIW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC    50
    PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI 100
    FSSFVFSTVV I 111
    Length:111
    Mass (Da):12,721
    Last modified:July 13, 2010 - v1
    Checksum:i0A3C08FEEEF1BE2E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei111 – 1111Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008897 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000507942; ENSP00000427340; ENSG00000113161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008897 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D6RIW0.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi D6RIW0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000507942 ; ENSP00000427340 ; ENSG00000113161 .

    Organism-specific databases

    HGNCi HGNC:5006. HMGCR.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000183489.

    Miscellaneous databases

    ChiTaRSi Hmgcr. human.
    NextBioi 35494930.

    Gene expression databases

    ArrayExpressi D6RIW0.
    Bgeei D6RIW0.

    Family and domain databases

    InterProi IPR002202. HMG_CoA_Rdtase.
    IPR000731. SSD.
    [Graphical view ]
    PANTHERi PTHR10572. PTHR10572. 1 hit.
    PROSITEi PS50156. SSD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiD6RIW0_HUMAN
    AccessioniPrimary (citable) accession number: D6RIW0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3