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Protein
Submitted name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: Ensembl
  3. hydroxymethylglutaryl-CoA reductase activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. cholesterol biosynthetic process Source: Ensembl
  3. coenzyme A metabolic process Source: InterPro
  4. myoblast differentiation Source: Ensembl
  5. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  6. negative regulation of MAP kinase activity Source: Ensembl
  7. negative regulation of striated muscle cell apoptotic process Source: Ensembl
  8. negative regulation of vasodilation Source: Ensembl
  9. negative regulation of wound healing Source: Ensembl
  10. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  12. positive regulation of skeletal muscle tissue development Source: Ensembl
  13. positive regulation of smooth muscle cell proliferation Source: Ensembl
  14. positive regulation of stress-activated MAPK cascade Source: Ensembl
  15. response to ethanol Source: Ensembl
  16. response to nutrient Source: Ensembl
  17. ubiquinone metabolic process Source: Ensembl
  18. visual learning Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseImported
Gene namesi
Name:HMGCRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:5006. HMGCR.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. intracellular membrane-bounded organelle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD6RIW0.
ExpressionAtlasiD6RIW0. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliD6RIW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119321.
HOGENOMiHOG000183489.

Family and domain databases

InterProiIPR002202. HMG_CoA_Rdtase.
IPR000731. SSD.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D6RIW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC
60 70 80 90 100
PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI
110
FSSFVFSTVV I
Length:111
Mass (Da):12,721
Last modified:July 13, 2010 - v1
Checksum:i0A3C08FEEEF1BE2E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei111 – 1111Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000507942; ENSP00000427340; ENSG00000113161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RIW0.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiD6RIW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000507942; ENSP00000427340; ENSG00000113161.

Organism-specific databases

HGNCiHGNC:5006. HMGCR.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119321.
HOGENOMiHOG000183489.

Miscellaneous databases

ChiTaRSiHMGCR. human.
NextBioi35494930.

Gene expression databases

BgeeiD6RIW0.
ExpressionAtlasiD6RIW0. baseline and differential.

Family and domain databases

InterProiIPR002202. HMG_CoA_Rdtase.
IPR000731. SSD.
[Graphical view]
PANTHERiPTHR10572. PTHR10572. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiD6RIW0_HUMAN
AccessioniPrimary (citable) accession number: D6RIW0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.