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Protein
Submitted name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseImported
Gene namesi
Name:HMGCRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113161.15
HGNCiHGNC:5006 HMGCR

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 37HelicalSequence analysisAdd BLAST18
Transmembranei57 – 78HelicalSequence analysisAdd BLAST22
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113161

PTM / Processingi

Proteomic databases

MaxQBiD6RIW0
PeptideAtlasiD6RIW0
PRIDEiD6RIW0

Expressioni

Gene expression databases

BgeeiENSG00000113161
ExpressionAtlasiD6RIW0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6RIW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 111SSDInterPro annotationAdd BLAST51

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2480 Eukaryota
COG1257 LUCA
GeneTreeiENSGT00910000144151
HOGENOMiHOG000183489

Family and domain databases

InterProiView protein in InterPro
IPR002202 HMG_CoA_Rdtase
IPR000731 SSD
PANTHERiPTHR10572 PTHR10572, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

Sequencei

Sequence statusi: Fragment.

D6RIW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC
60 70 80 90 100
PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI
110
FSSFVFSTVV I
Length:111
Mass (Da):12,721
Last modified:July 13, 2010 - v1
Checksum:i0A3C08FEEEF1BE2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei111Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000507942; ENSP00000427340; ENSG00000113161
UCSCiuc063epq.1 human

Similar proteinsi

Entry informationi

Entry nameiD6RIW0_HUMAN
AccessioniPrimary (citable) accession number: D6RIW0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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