ID   D6RHH7_HUMAN            Unreviewed;       238 AA.
AC   D6RHH7;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   RecName: Full=Corticotropin-releasing factor-binding protein {ECO:0000256|ARBA:ARBA00015713};
DE   AltName: Full=Corticotropin-releasing hormone-binding protein {ECO:0000256|ARBA:ARBA00033162};
GN   Name=CRHBP {ECO:0000313|Ensembl:ENSP00000426097.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426097.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426097.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426097.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Binds CRF and inactivates it. May prevent inappropriate
CC       pituitary-adrenal stimulation in pregnancy.
CC       {ECO:0000256|ARBA:ARBA00024997}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the CRF-binding protein family.
CC       {ECO:0000256|ARBA:ARBA00008313}.
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DR   EMBL; AC027342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6RHH7; -.
DR   MassIVE; D6RHH7; -.
DR   PeptideAtlas; D6RHH7; -.
DR   ProteomicsDB; 14840; -.
DR   Antibodypedia; 24474; 228 antibodies from 26 providers.
DR   Ensembl; ENST00000506501.1; ENSP00000426097.1; ENSG00000145708.11.
DR   UCSC; uc010izx.4; human.
DR   HGNC; HGNC:2356; CRHBP.
DR   VEuPathDB; HostDB:ENSG00000145708; -.
DR   GeneTree; ENSGT00390000001362; -.
DR   ChiTaRS; CRHBP; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000145708; Expressed in primordial germ cell in gonad and 114 other cell types or tissues.
DR   ExpressionAtlas; D6RHH7; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0051424; F:corticotropin-releasing hormone binding; IEA:InterPro.
DR   Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR   InterPro; IPR008435; CRF-bd.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR10278; CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN; 1.
DR   PANTHER; PTHR10278:SF0; CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN; 1.
DR   Pfam; PF05428; CRF-BP; 1.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:D6RHH7,
KW   ECO:0007829|ProteomicsDB:D6RHH7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..238
FT                   /note="Corticotropin-releasing factor-binding protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003087608"
SQ   SEQUENCE   238 AA;  27082 MW;  4CFC8A9615B79A73 CRC64;
     MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC
     LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG
     EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL
     FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KVSCLLVS
//