ID   D6RHG0_HUMAN            Unreviewed;       248 AA.
AC   D6RHG0;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 9.
DT   27-MAR-2024, entry version 81.
DE   RecName: Full=Solute carrier family 35 member B1 {ECO:0000256|ARBA:ARBA00040754};
DE   Flags: Fragment;
GN   Name=SLC35B1 {ECO:0000313|Ensembl:ENSP00000427689.3};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427689.3, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427689.3, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0007829|PubMed:22814378}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [3] {ECO:0000313|Ensembl:ENSP00000427689.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000256|ARBA:ARBA00010694}.
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DR   EMBL; AC015795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6RHG0; -.
DR   SMR; D6RHG0; -.
DR   IntAct; D6RHG0; 2.
DR   MassIVE; D6RHG0; -.
DR   PeptideAtlas; D6RHG0; -.
DR   ProteomicsDB; 14827; -.
DR   Antibodypedia; 17968; 74 antibodies from 19 providers.
DR   Ensembl; ENST00000515850.6; ENSP00000427689.3; ENSG00000121073.15.
DR   UCSC; uc060hcp.1; human.
DR   HGNC; HGNC:20798; SLC35B1.
DR   VEuPathDB; HostDB:ENSG00000121073; -.
DR   GeneTree; ENSGT00940000157900; -.
DR   ChiTaRS; SLC35B1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000121073; Expressed in islet of Langerhans and 202 other cell types or tissues.
DR   ExpressionAtlas; D6RHG0; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.10.3730.20; -; 1.
DR   InterPro; IPR013657; SCL35B1-4/HUT1.
DR   PANTHER; PTHR10778; SOLUTE CARRIER FAMILY 35 MEMBER B; 1.
DR   PANTHER; PTHR10778:SF10; SOLUTE CARRIER FAMILY 35 MEMBER B1; 1.
DR   Pfam; PF08449; UAA; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:D6RHG0,
KW   ECO:0007829|PeptideAtlas:D6RHG0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        83..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        172..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   NON_TER         248
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000427689.3"
SQ   SEQUENCE   248 AA;  27645 MW;  ACCA928745872FD7 CRC64;
     MASSSSLVPD RLRLPLCFLG VFVCYFYYGI LQEKMTRVGP LLVLPDACKQ PIRPRPWCHS
     RNTVSSCLGT RGKYGEGAKQ ETFTFALTLV FIQCVINAVF AKILIQFFDT ARVDRTRSWL
     YAACSISYLG AMVSSNSALQ FVNYPTQVLG KSCKPIPVML LGVTLLKKKY PLAKYLCVLL
     IVAGVALFMY KPKKVVGIEE HTVGYGELLL LLSLTLDGLT GVSQDHMRAH YQTGSNHMML
     NINLWSTL
//