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Protein
Submitted name:

Serum albumin

Gene

ALB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Serum albuminImported
Gene namesi
Name:ALBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:399. ALB.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163631.

Protein family/group databases

Allergomei763. Hom s HSA.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 51PROSITE-ProRule annotation
Disulfide bondi74 ↔ 120PROSITE-ProRule annotation
Disulfide bondi119 ↔ 127PROSITE-ProRule annotation
Disulfide bondi152 ↔ 163PROSITE-ProRule annotation
Disulfide bondi190 ↔ 235PROSITE-ProRule annotation
Disulfide bondi234 ↔ 243PROSITE-ProRule annotation
Disulfide bondi266 ↔ 312PROSITE-ProRule annotation
Disulfide bondi311 ↔ 319PROSITE-ProRule annotation
Disulfide bondi350 ↔ 361PROSITE-ProRule annotation
Disulfide bondi388 ↔ 433PROSITE-ProRule annotation
Disulfide bondi432 ↔ 441PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiD6RHD5.
PeptideAtlasiD6RHD5.
PRIDEiD6RHD5.

Expressioni

Gene expression databases

BgeeiENSG00000163631.
ExpressionAtlasiD6RHD5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD6RHD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 60AlbuminInterPro annotationAdd BLAST60
Domaini61 – 253AlbuminInterPro annotationAdd BLAST193
Domaini254 – 451AlbuminInterPro annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
GeneTreeiENSGT00390000000113.
HOGENOMiHOG000293137.

Family and domain databases

CDDicd00015. ALBUMIN. 2 hits.
InterProiView protein in InterPro
IPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
PANTHERiPTHR11385. PTHR11385. 1 hit.
PfamiView protein in Pfam
PF00273. Serum_albumin. 3 hits.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiView protein in SMART
SM00103. ALBUMIN. 2 hits.
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiView protein in PROSITE
PS00212. ALBUMIN_1. 2 hits.
PS51438. ALBUMIN_2. 3 hits.

Sequencei

Sequence statusi: Complete.

D6RHD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLKIVTNH LYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA
60 70 80 90 100
CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA
110 120 130 140 150
EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK
160 170 180 190 200
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF
210 220 230 240 250
LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE
260 270 280 290 300
FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV
310 320 330 340 350
SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC
360 370 380 390 400
CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ
410 420 430 440 450
TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV

AASQAALGL
Length:459
Mass (Da):52,059
Last modified:July 13, 2010 - v1
Checksum:i9CACF9DE5327EC6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108157 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000503124; ENSP00000421027; ENSG00000163631.
UCSCiuc062xfu.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD6RHD5_HUMAN
AccessioniPrimary (citable) accession number: D6RHD5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 5, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported