Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Serine/threonine-protein kinase N1

Gene

Pkn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • B cell apoptotic process Source: MGI
  • B cell homeostasis Source: MGI
  • epithelial cell migration Source: MGI
  • histone H3-T11 phosphorylation Source: MGI
  • hyperosmotic response Source: MGI
  • negative regulation of B cell proliferation Source: MGI
  • negative regulation of protein kinase activity Source: MGI
  • negative regulation of protein phosphorylation Source: MGI
  • protein phosphorylation Source: MGI
  • regulation of cell motility Source: MGI
  • regulation of germinal center formation Source: MGI
  • regulation of immunoglobulin production Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • renal system process Source: MGI
  • signal transduction Source: InterPro
  • spleen development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase N1Imported
Gene namesi
Name:Pkn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:108022. Pkn1.

Subcellular locationi

GO - Cellular componenti

  • cleavage furrow Source: MGI
  • cytoplasm Source: MGI
  • cytoplasmic membrane-bounded vesicle Source: MGI
  • endosome Source: MGI
  • midbody Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD6RH37.

Expressioni

Gene expression databases

BgeeiD6RH37.
ExpressionAtlasiD6RH37. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116235.

Structurei

3D structure databases

ProteinModelPortaliD6RH37.
SMRiD6RH37. Positions 25-110, 137-202, 590-791.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00770000120523.
HOGENOMiHOG000233032.

Family and domain databases

Gene3Di1.10.287.160. 3 hits.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR011072. HR1_rho-bd.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF02185. HR1. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00742. Hr1. 3 hits.
[Graphical view]
SUPFAMiSSF46585. SSF46585. 3 hits.
SSF49562. SSF49562. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6RH37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACRPCRGAG RIWCCRSHKS EPRSWSLLEQ LGLAGADLAA PGVQQQLELE
60 70 80 90 100
RERLKREIRK ELKLKEGAEN LRRATTDLGR SLAPVELLLR GSARRLDLLH
110 120 130 140 150
QQLQELHAHV VLPDPAAGSD ATQSLAEGSP ICSSTNLSRV AGLEKQLAIE
160 170 180 190 200
LKVKQGAENM IQTYSNGSSK DRKLLLTAQQ MLQDSKTKID IIRMQLRRAL
210 220 230 240 250
QALQAGELES QAAPDEAQGD PELGAVELRI EELRHHFRVE HAVAEGAKNV
260 270 280 290 300
LRLLSGAKAP DRKAVSEAQE KLTESNQKLG LLRESLERRL GELPADHPKG
310 320 330 340 350
RLLREELTAA SSSAFSAILP GPFPATHYST LSKPAPLTGT LEVRVVGCKN
360 370 380 390 400
LPETIPWSPP PSVGASGTPE SRTPFLSRPA RGLYSRSGSL SGRSSLRGEA
410 420 430 440 450
ENATEVSTVL KLDNTVVGQT AWKPCGPNAW DQSFTLELER ARELELAVFW
460 470 480 490 500
RDQRGLCALK FLKLEDFLDN ERHEVQLDME PQGCLVAEVT FRNPIIERIP
510 520 530 540 550
RLQRQKKIFS KQQGKAFQRA RQMNIDVATW VRLLRRLIPS AVATGTFSPN
560 570 580 590 600
ASPGAEIRHT GDISMEKLNL GADSDSSSQK SPPGLPSTSC SLSSPTHEST
610 620 630 640 650
TSPELPSETQ ETPGPGLCSP LRKSPLTLED FKFLAVLGRG HFGKVLLSEF
660 670 680 690 700
RSSGELFAIK ALKKGDIVAR DEVESLMCEK RILAAVTRAG HPFLVNLFGC
710 720 730 740 750
FQTPEHVCFV MEYSAGGDLM LHIHSDVFSE PRAVFYSACV VLGLQFLHEH
760 770 780 790
KIVYRDGLWG PDQHVLRNSG VPGAGSAHRH ILHASSGLVG TGRAAL
Length:796
Mass (Da):87,195
Last modified:July 13, 2010 - v1
Checksum:iF772A7521BB81523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164432 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000132945; ENSMUSP00000115054; ENSMUSG00000057672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164432 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RH37.
SMRiD6RH37. Positions 25-110, 137-202, 590-791.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116235.

Proteomic databases

PRIDEiD6RH37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000132945; ENSMUSP00000115054; ENSMUSG00000057672.

Organism-specific databases

MGIiMGI:108022. Pkn1.

Phylogenomic databases

GeneTreeiENSGT00770000120523.
HOGENOMiHOG000233032.

Miscellaneous databases

ChiTaRSiPkn1. mouse.
NextBioi35552404.
SOURCEiSearch...

Gene expression databases

BgeeiD6RH37.
ExpressionAtlasiD6RH37. baseline and differential.

Family and domain databases

Gene3Di1.10.287.160. 3 hits.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR011072. HR1_rho-bd.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF02185. HR1. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00742. Hr1. 3 hits.
[Graphical view]
SUPFAMiSSF46585. SSF46585. 3 hits.
SSF49562. SSF49562. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD6RH37_MOUSE
AccessioniPrimary (citable) accession number: D6RH37
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 24, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.