ID   D6RH31_HUMAN            Unreviewed;       609 AA.
AC   D6RH31;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Nephronectin {ECO:0000313|Ensembl:ENSP00000426146.1};
DE   Flags: Fragment;
GN   Name=NPNT {ECO:0000313|Ensembl:ENSP00000426146.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426146.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000426146.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000426146.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the nephronectin family.
CC       {ECO:0000256|ARBA:ARBA00009738}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC093782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6RH31; -.
DR   SMR; D6RH31; -.
DR   MassIVE; D6RH31; -.
DR   PeptideAtlas; D6RH31; -.
DR   ProteomicsDB; 14797; -.
DR   Antibodypedia; 1021; 144 antibodies from 23 providers.
DR   Ensembl; ENST00000503451.5; ENSP00000426146.1; ENSG00000168743.13.
DR   UCSC; uc062yue.1; human.
DR   HGNC; HGNC:27405; NPNT.
DR   VEuPathDB; HostDB:ENSG00000168743; -.
DR   GeneTree; ENSGT00930000150973; -.
DR   PhylomeDB; D6RH31; -.
DR   ChiTaRS; NPNT; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000168743; Expressed in right lobe of thyroid gland and 166 other cell types or tissues.
DR   ExpressionAtlas; D6RH31; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd00054; EGF_CA; 2.
DR   CDD; cd06263; MAM; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 5.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR000998; MAM_dom.
DR   PANTHER; PTHR24050:SF19; NEPHRONECTIN; 1.
DR   PANTHER; PTHR24050; PA14 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF00629; MAM; 1.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00179; EGF_CA; 3.
DR   SMART; SM00137; MAM; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS50060; MAM_2; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   Proteomics identification {ECO:0007829|MaxQB:D6RH31,
KW   ECO:0007829|PeptideAtlas:D6RH31};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..609
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003087444"
FT   DOMAIN          136..175
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          216..260
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          261..301
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          467..609
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   REGION          348..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..395
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         609
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000426146.1"
SQ   SEQUENCE   609 AA;  66916 MW;  0E54C2FDA351B1A7 CRC64;
     MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPFY
     VLRQRIARIR CQLKAVCQPR CKHGECIGPN KCKCHPGYAG KTCNQDEHIP APLDQGSEQP
     LFQPLDHQAT SLPSRDLNEC GLKPRPCKHR CMNTYGSYKC YCLNGYMLMP DGSCSSALTC
     SMANCQYGCD VVKGQIRCQC PSPGLQLAPD GRTCVDVDEC ATGRASCPRF RQCVNTFGSY
     ICKCHKGFDL MYIGGKYQCH DIDECSLGQY QCSSFARCYN IRGSYKCKCK EGYQGDGLTC
     VYIPKVMIEP SGPIHVPKGN GTILKGDTGN NNWIPDVGST WWPPKTPYIP PIITNRPTSK
     PTTRPTPKPT PIPTPPPPPP LPTELRTPLP PTTPERPTTG LTTIAPAAST PPGGITVDNR
     VQTDPQKPRG DVFIPRQPSN DLFEIFEIER GVSADDEAKD DPGVLVHSCN FDHGLCGWIR
     EKDNDLHWEP IRDPAGGQYL TVSAAKAPGG KAARLVLPLG RLMHSGDLCL SFRHKVTGLH
     SGTLQVFVRK HGAHGAALWG RNGGHGWRQT QITLRGADIK SVVFKGEKRR GHTGEIGLDD
     VSLKKGHCS
//