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Protein
Submitted name:

Nephronectin

Gene

NPNT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
NephronectinImported
Gene namesi
Name:NPNTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168743.12.
HGNCiHGNC:27405. NPNT.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500308744420 – 609Sequence analysisAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 103PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiD6RH31.
PeptideAtlasiD6RH31.
PRIDEiD6RH31.

Expressioni

Gene expression databases

BgeeiENSG00000168743.
ExpressionAtlasiD6RH31. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000389252.

Structurei

3D structure databases

ProteinModelPortaliD6RH31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 104EGF-likeInterPro annotationAdd BLAST32
Domaini136 – 175EGF-likeInterPro annotationAdd BLAST40
Domaini216 – 260EGF-likeInterPro annotationAdd BLAST45
Domaini261 – 301EGF-likeInterPro annotationAdd BLAST41
Domaini467 – 609MAMInterPro annotationAdd BLAST143

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR6Z. Eukaryota.
ENOG411039V. LUCA.
GeneTreeiENSGT00860000133741.
HOGENOMiHOG000059638.
OMAiCPRFRQC.
OrthoDBiEOG091G02IF.
PhylomeDBiD6RH31.

Family and domain databases

CDDicd06263. MAM. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR000998. MAM_dom.
PfamiView protein in Pfam
PF07645. EGF_CA. 3 hits.
PF00629. MAM. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 3 hits.
SM00137. MAM. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS50060. MAM_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

D6RH31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR
60 70 80 90 100
QSWGQCQPFY VLRQRIARIR CQLKAVCQPR CKHGECIGPN KCKCHPGYAG
110 120 130 140 150
KTCNQDEHIP APLDQGSEQP LFQPLDHQAT SLPSRDLNEC GLKPRPCKHR
160 170 180 190 200
CMNTYGSYKC YCLNGYMLMP DGSCSSALTC SMANCQYGCD VVKGQIRCQC
210 220 230 240 250
PSPGLQLAPD GRTCVDVDEC ATGRASCPRF RQCVNTFGSY ICKCHKGFDL
260 270 280 290 300
MYIGGKYQCH DIDECSLGQY QCSSFARCYN IRGSYKCKCK EGYQGDGLTC
310 320 330 340 350
VYIPKVMIEP SGPIHVPKGN GTILKGDTGN NNWIPDVGST WWPPKTPYIP
360 370 380 390 400
PIITNRPTSK PTTRPTPKPT PIPTPPPPPP LPTELRTPLP PTTPERPTTG
410 420 430 440 450
LTTIAPAAST PPGGITVDNR VQTDPQKPRG DVFIPRQPSN DLFEIFEIER
460 470 480 490 500
GVSADDEAKD DPGVLVHSCN FDHGLCGWIR EKDNDLHWEP IRDPAGGQYL
510 520 530 540 550
TVSAAKAPGG KAARLVLPLG RLMHSGDLCL SFRHKVTGLH SGTLQVFVRK
560 570 580 590 600
HGAHGAALWG RNGGHGWRQT QITLRGADIK SVVFKGEKRR GHTGEIGLDD

VSLKKGHCS
Length:609
Mass (Da):66,916
Last modified:July 13, 2010 - v1
Checksum:i0E54C2FDA351B1A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei609Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093782 Genomic DNA. No translation available.
AC109361 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000503451; ENSP00000426146; ENSG00000168743.
UCSCiuc062yue.1. human.

Similar proteinsi

Entry informationi

Entry nameiD6RH31_HUMAN
AccessioniPrimary (citable) accession number: D6RH31
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 27, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported