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Protein
Submitted name:

Nephronectin

Gene

NPNT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
NephronectinImported
Gene namesi
Name:NPNTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168743.12
HGNCiHGNC:27405 NPNT

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168743

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500308744420 – 609Sequence analysisAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 103PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiD6RH31
PeptideAtlasiD6RH31
PRIDEiD6RH31

Expressioni

Gene expression databases

BgeeiENSG00000168743
ExpressionAtlasiD6RH31 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000389252

Structurei

3D structure databases

ProteinModelPortaliD6RH31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 104EGF-likeInterPro annotationAdd BLAST32
Domaini136 – 175EGF-likeInterPro annotationAdd BLAST40
Domaini216 – 260EGF-likeInterPro annotationAdd BLAST45
Domaini261 – 301EGF-likeInterPro annotationAdd BLAST41
Domaini467 – 609MAMInterPro annotationAdd BLAST143

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR6Z Eukaryota
ENOG411039V LUCA
GeneTreeiENSGT00810000125382
HOGENOMiHOG000059638
OMAiCPRFRQC
OrthoDBiEOG091G02IF
PhylomeDBiD6RH31

Family and domain databases

CDDicd06263 MAM, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR000998 MAM_dom
PfamiView protein in Pfam
PF07645 EGF_CA, 3 hits
PF00629 MAM, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 3 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS50060 MAM_2, 1 hit

Sequencei

Sequence statusi: Fragment.

D6RH31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR
60 70 80 90 100
QSWGQCQPFY VLRQRIARIR CQLKAVCQPR CKHGECIGPN KCKCHPGYAG
110 120 130 140 150
KTCNQDEHIP APLDQGSEQP LFQPLDHQAT SLPSRDLNEC GLKPRPCKHR
160 170 180 190 200
CMNTYGSYKC YCLNGYMLMP DGSCSSALTC SMANCQYGCD VVKGQIRCQC
210 220 230 240 250
PSPGLQLAPD GRTCVDVDEC ATGRASCPRF RQCVNTFGSY ICKCHKGFDL
260 270 280 290 300
MYIGGKYQCH DIDECSLGQY QCSSFARCYN IRGSYKCKCK EGYQGDGLTC
310 320 330 340 350
VYIPKVMIEP SGPIHVPKGN GTILKGDTGN NNWIPDVGST WWPPKTPYIP
360 370 380 390 400
PIITNRPTSK PTTRPTPKPT PIPTPPPPPP LPTELRTPLP PTTPERPTTG
410 420 430 440 450
LTTIAPAAST PPGGITVDNR VQTDPQKPRG DVFIPRQPSN DLFEIFEIER
460 470 480 490 500
GVSADDEAKD DPGVLVHSCN FDHGLCGWIR EKDNDLHWEP IRDPAGGQYL
510 520 530 540 550
TVSAAKAPGG KAARLVLPLG RLMHSGDLCL SFRHKVTGLH SGTLQVFVRK
560 570 580 590 600
HGAHGAALWG RNGGHGWRQT QITLRGADIK SVVFKGEKRR GHTGEIGLDD

VSLKKGHCS
Length:609
Mass (Da):66,916
Last modified:July 13, 2010 - v1
Checksum:i0E54C2FDA351B1A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei609Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093782 Genomic DNA No translation available.
AC109361 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000503451; ENSP00000426146; ENSG00000168743
UCSCiuc062yue.1 human

Similar proteinsi

Entry informationi

Entry nameiD6RH31_HUMAN
AccessioniPrimary (citable) accession number: D6RH31
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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