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Protein
Submitted name:

Interleukin-6 receptor subunit beta

Gene

IL6ST

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-6 receptor subunit betaImported
Gene namesi
Name:IL6STImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6021. IL6ST.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500308765623 – 333Sequence analysisAdd BLAST311

Proteomic databases

MaxQBiD6RH03.
PaxDbiD6RH03.
PeptideAtlasiD6RH03.
PRIDEiD6RH03.

Expressioni

Gene expression databases

BgeeiENSG00000134352.
ExpressionAtlasiD6RH03. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000338799.

Structurei

3D structure databases

ProteinModelPortaliD6RH03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 324Fibronectin type-IIIInterPro annotationAdd BLAST101

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IF1N. Eukaryota.
ENOG410YNQ4. LUCA.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000171665.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6RH03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL
60 70 80 90 100
KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ
110 120 130 140 150
LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR
160 170 180 190 200
ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA
210 220 230 240 250
ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK
260 270 280 290 300
SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR
310 320 330
CMKEDGKGYW SDWSEEASGI TYEDTLDKPL GSG
Length:333
Mass (Da):37,835
Last modified:July 13, 2010 - v1
Checksum:iE87A56334BE0953B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008914 Genomic DNA. No translation available.
AC016596 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000503773; ENSP00000426224; ENSG00000134352.
UCSCiuc063dsa.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008914 Genomic DNA. No translation available.
AC016596 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RH03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000338799.

Proteomic databases

MaxQBiD6RH03.
PaxDbiD6RH03.
PeptideAtlasiD6RH03.
PRIDEiD6RH03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503773; ENSP00000426224; ENSG00000134352.
UCSCiuc063dsa.1. human.

Organism-specific databases

CTDi3572.
HGNCiHGNC:6021. IL6ST.
OpenTargetsiENSG00000134352.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF1N. Eukaryota.
ENOG410YNQ4. LUCA.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000171665.

Miscellaneous databases

ChiTaRSiIL6ST. human.
GenomeRNAii3572.

Gene expression databases

BgeeiENSG00000134352.
ExpressionAtlasiD6RH03. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR010457. IgC2-like_lig-bd.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF09240. IL6Ra-bind. 1 hit.
PF06328. Lep_receptor_Ig. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6RH03_HUMAN
AccessioniPrimary (citable) accession number: D6RH03
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.