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Protein
Submitted name:

Bone morphogenetic protein receptor type-1B

Gene

BMPR1B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta receptor activity, type I Source: Ensembl

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. cartilage condensation Source: Ensembl
  3. chondrocyte differentiation Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. inflammatory response Source: Ensembl
  6. ovarian cumulus expansion Source: Ensembl
  7. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  8. retina development in camera-type eye Source: Ensembl
  9. retinal ganglion cell axon guidance Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bone morphogenetic protein receptor type-1BImported
Gene namesi
Name:BMPR1BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:1077. BMPR1B.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD6RGW8.
ExpressionAtlasiD6RGW8. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliD6RGW8.
SMRiD6RGW8. Positions 29-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118876.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D6RGW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLRSAGKLN VGTKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD
60 70 80 90 100
GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN
110 120
ECNKDLHPTL PPLKNRDFVD GPIHH
Length:125
Mass (Da):13,900
Last modified:February 8, 2011 - v1
Checksum:i6DFA6903D499F5F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei125 – 1251Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004061 Genomic DNA. No translation available.
AC092609 Genomic DNA. No translation available.
AC093634 Genomic DNA. No translation available.
AC105395 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000506363; ENSP00000421144; ENSG00000138696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004061 Genomic DNA. No translation available.
AC092609 Genomic DNA. No translation available.
AC093634 Genomic DNA. No translation available.
AC105395 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RGW8.
SMRiD6RGW8. Positions 29-113.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiD6RGW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506363; ENSP00000421144; ENSG00000138696.

Organism-specific databases

HGNCiHGNC:1077. BMPR1B.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118876.

Miscellaneous databases

ChiTaRSiBMPR1B. human.
NextBioi35494651.

Gene expression databases

BgeeiD6RGW8.
ExpressionAtlasiD6RGW8. baseline and differential.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiD6RGW8_HUMAN
AccessioniPrimary (citable) accession number: D6RGW8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: January 7, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.