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Protein
Submitted name:

Interleukin-7 receptor subunit alpha

Gene

IL7R

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-7 receptor subunit alphaImported
Gene namesi
Name:IL7RImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6024. IL7R.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500308765121 – 261Sequence analysisAdd BLAST241

Proteomic databases

MaxQBiD6RGV2.
PaxDbiD6RGV2.
PeptideAtlasiD6RGV2.
PRIDEiD6RGV2.

Expressioni

Gene expression databases

BgeeiENSG00000168685.
ExpressionAtlasiD6RGV2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306157.

Structurei

3D structure databases

ProteinModelPortaliD6RGV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 231Fibronectin type-IIIInterPro annotationAdd BLAST101

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IGXR. Eukaryota.
ENOG410YWZG. LUCA.
GeneTreeiENSGT00510000048500.
HOGENOMiHOG000089950.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6RGV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG
60 70 80 90 100
SQHSLTCAFE DPDVNITNLE FEICGALVEV KCLNFRKLQE IYFIETKKFL
110 120 130 140 150
LIGKSNICVK VGEKSLTCKK IDLTTIVKPE APFDLSVVYR EGANDFVVTF
160 170 180 190 200
NTSHLQKKYV KVLMHDVAYR QEKDENKWTH VNLSSTKLTL LQRKLQPAAM
210 220 230 240 250
YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSSGLSLS YGPVSPIIRR
260
LWNIFVRNQE K
Length:261
Mass (Da):29,936
Last modified:July 13, 2010 - v1
Checksum:i7E74A79A067977AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112204 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000506850; ENSP00000421207; ENSG00000168685.
UCSCiuc011coo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112204 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RGV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306157.

Proteomic databases

MaxQBiD6RGV2.
PaxDbiD6RGV2.
PeptideAtlasiD6RGV2.
PRIDEiD6RGV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506850; ENSP00000421207; ENSG00000168685.
UCSCiuc011coo.4. human.

Organism-specific databases

CTDi3575.
HGNCiHGNC:6024. IL7R.
OpenTargetsiENSG00000168685.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGXR. Eukaryota.
ENOG410YWZG. LUCA.
GeneTreeiENSGT00510000048500.
HOGENOMiHOG000089950.

Miscellaneous databases

GenomeRNAii3575.

Gene expression databases

BgeeiENSG00000168685.
ExpressionAtlasiD6RGV2. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6RGV2_HUMAN
AccessioniPrimary (citable) accession number: D6RGV2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.