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D6RGH6

- MCIN_HUMAN

UniProt

D6RGH6 - MCIN_HUMAN

Protein

Multicilin

Gene

MCIDAS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Transcription regulator required for multiciliate cell differentiation. Acts by promoting transcription of genes required for multiciliate cell formation. Probably acts in a multiprotein complex By similarity. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1.By similarity2 Publications

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cilium assembly Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. regulation of DNA replication Source: InterPro
    5. regulation of mitotic cell cycle Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cilium biogenesis/degradation, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multicilin
    Alternative name(s):
    Multiciliate differentiation and DNA synthesis-associated cell cycle protein
    Protein Idas
    Gene namesi
    Name:MCIDAS
    Synonyms:IDAS, MCI, MCIN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:40050. MCIDAS.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Excluded from the nucleolus.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385MulticilinPRO_0000411076Add
    BLAST

    Expressioni

    Developmental stagei

    Probable target of the anaphase promoting complex/cyclosome (APC/C) which regulates its level in the cell during the mitotic cell cycle. Highly expressed during interphase and early mitosis. Expression decreases during anaphase to become undetectable during telophase and cytokinesis.1 Publication

    Organism-specific databases

    HPAiHPA049981.

    Interactioni

    Subunit structurei

    Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-3954372,EBI-3954372
    GMNNO754967EBI-3954372,EBI-371669

    Protein-protein interaction databases

    IntActiD6RGH6. 1 interaction.

    Structurei

    Secondary structure

    1
    385
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi178 – 22548
    Helixi227 – 24115

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BRYX-ray2.89B173-245[»]
    ProteinModelPortaliD6RGH6.
    SMRiD6RGH6. Positions 176-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 130130Necessary and sufficient for its degradation during the cell cycleAdd
    BLAST
    Regioni131 – 385255Necessary and sufficient for proper nuclear localizationAdd
    BLAST
    Regioni173 – 24573Necessary and sufficient for interaction with GMNN and sufficient for homodimerizationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili179 – 227491 PublicationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the geminin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOGENOMiHOG000133078.
    KOiK10749.
    OMAiGYKFRWV.
    PhylomeDBiD6RGH6.

    Family and domain databases

    InterProiIPR022786. Geminin/Multicilin.
    IPR029699. Multicilin/Idas.
    [Graphical view]
    PANTHERiPTHR13372:SF3. PTHR13372:SF3. 1 hit.
    PfamiPF07412. Geminin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6RGH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQACGGGAAG RRAFDSICPN RMLALPGRAL LCKPGKPERK FAPPRKFFPG    50
    CTGGSPVSVY EDPPDAEPTA LPALTTIDLQ DLADCSSLLG SDAPPGGDLA 100
    ASQNHSHQTE ADFNLQDFRD TVDDLISDSS SMMSPTLASG DFPFSPCDIS 150
    PFGPCLSPPL DPRALQSPPL RPPDVPPPEQ YWKEVADQNQ RALGDALVEN 200
    NQLHVTLTQK QEEIASLKER NVQLKELASR TRHLASVLDK LMITQSRDCG 250
    AAAEPFLLKA KAKRSLEELV SAAGQDCAEV DAILREISER CDEALQSRDP 300
    KRPRLLPEPA NTDTRPGNLH GAFRGLRTDC SRSALNLSHS ELEEGGSFST 350
    RIRSHSTIRT LAFPQGNAFT IRTANGGYKF RWVPS 385
    Length:385
    Mass (Da):41,720
    Last modified:July 13, 2010 - v1
    Checksum:iD52A35B926E75723
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR854393 mRNA. Translation: CCA89438.1.
    AC091977 Genomic DNA. No translation available.
    CCDSiCCDS54853.1.
    RefSeqiNP_001177716.1. NM_001190787.1.
    UniGeneiHs.394578.

    Genome annotation databases

    EnsembliENST00000513312; ENSP00000426359; ENSG00000234602.
    GeneIDi345643.
    KEGGihsa:345643.
    UCSCiuc021xyp.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR854393 mRNA. Translation: CCA89438.1 .
    AC091977 Genomic DNA. No translation available.
    CCDSi CCDS54853.1.
    RefSeqi NP_001177716.1. NM_001190787.1.
    UniGenei Hs.394578.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BRY X-ray 2.89 B 173-245 [» ]
    ProteinModelPortali D6RGH6.
    SMRi D6RGH6. Positions 176-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi D6RGH6. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000513312 ; ENSP00000426359 ; ENSG00000234602 .
    GeneIDi 345643.
    KEGGi hsa:345643.
    UCSCi uc021xyp.1. human.

    Organism-specific databases

    CTDi 345643.
    GeneCardsi GC05M054521.
    HGNCi HGNC:40050. MCIDAS.
    HPAi HPA049981.
    MIMi 614086. gene.
    neXtProti NX_D6RGH6.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000133078.
    KOi K10749.
    OMAi GYKFRWV.
    PhylomeDBi D6RGH6.

    Miscellaneous databases

    GenomeRNAii 345643.
    NextBioi 98889.
    PROi D6RGH6.
    SOURCEi Search...

    Family and domain databases

    InterProi IPR022786. Geminin/Multicilin.
    IPR029699. Multicilin/Idas.
    [Graphical view ]
    PANTHERi PTHR13372:SF3. PTHR13372:SF3. 1 hit.
    Pfami PF07412. Geminin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression."
      Pefani D.E., Dimaki M., Spella M., Karantzelis N., Mitsiki E., Kyrousi C., Symeonidou I.E., Perrakis A., Taraviras S., Lygerou Z.
      J. Biol. Chem. 286:23234-23246(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GMNN, HOMODIMERIZATION, SUBUNIT, DEVELOPMENTAL STAGE.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing."
      Caillat C., Pefani E.D., Gillespie P.J., Taraviras S., Blow J.J., Lygerou Z., Perrakis A.
      J. Biol. Chem. 288:31624-31634(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 173-245 IN COMPLEX WITH GMNN, FUNCTION, COILED-COIL DOMAIN, SUBUNIT.

    Entry informationi

    Entry nameiMCIN_HUMAN
    AccessioniPrimary (citable) accession number: D6RGH6
    Secondary accession number(s): C9JGY3, D6R920, F8KGQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Was named Idas in reference to the cousin of the Gemini in ancient Greek mythology.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3