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D6RGH6

- MCIN_HUMAN

UniProt

D6RGH6 - MCIN_HUMAN

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Protein

Multicilin

Gene
MCIDAS, IDAS, MCI, MCIN
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription regulator required for multiciliate cell differentiation. Acts by promoting transcription of genes required for multiciliate cell formation. Probably acts in a multiprotein complex By similarity. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1.2 Publications

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. protein binding Source: IntAct

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cilium assembly Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. regulation of DNA replication Source: InterPro
  5. regulation of mitotic cell cycle Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cilium biogenesis/degradation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Multicilin
Alternative name(s):
Multiciliate differentiation and DNA synthesis-associated cell cycle protein
Protein Idas
Gene namesi
Name:MCIDAS
Synonyms:IDAS, MCI, MCIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:40050. MCIDAS.

Subcellular locationi

Nucleus
Note: Excluded from the nucleolus.1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385MulticilinPRO_0000411076Add
BLAST

Expressioni

Developmental stagei

Probable target of the anaphase promoting complex/cyclosome (APC/C) which regulates its level in the cell during the mitotic cell cycle. Highly expressed during interphase and early mitosis. Expression decreases during anaphase to become undetectable during telophase and cytokinesis.1 Publication

Organism-specific databases

HPAiHPA049981.

Interactioni

Subunit structurei

Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-3954372,EBI-3954372
GMNNO754967EBI-3954372,EBI-371669

Protein-protein interaction databases

IntActiD6RGH6. 1 interaction.

Structurei

Secondary structure

1
385
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi178 – 22548
Helixi227 – 24115

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BRYX-ray2.89B173-245[»]
ProteinModelPortaliD6RGH6.
SMRiD6RGH6. Positions 176-244.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 130130Necessary and sufficient for its degradation during the cell cycleAdd
BLAST
Regioni131 – 385255Necessary and sufficient for proper nuclear localizationAdd
BLAST
Regioni173 – 24573Necessary and sufficient for interaction with GMNN and sufficient for homodimerizationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili179 – 227491 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the geminin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000133078.
KOiK10749.
OMAiGYKFRWV.
PhylomeDBiD6RGH6.

Family and domain databases

InterProiIPR022786. Geminin/Multicilin.
IPR029699. Multicilin/Idas.
[Graphical view]
PANTHERiPTHR13372:SF3. PTHR13372:SF3. 1 hit.
PfamiPF07412. Geminin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6RGH6-1 [UniParc]FASTAAdd to Basket

« Hide

MQACGGGAAG RRAFDSICPN RMLALPGRAL LCKPGKPERK FAPPRKFFPG    50
CTGGSPVSVY EDPPDAEPTA LPALTTIDLQ DLADCSSLLG SDAPPGGDLA 100
ASQNHSHQTE ADFNLQDFRD TVDDLISDSS SMMSPTLASG DFPFSPCDIS 150
PFGPCLSPPL DPRALQSPPL RPPDVPPPEQ YWKEVADQNQ RALGDALVEN 200
NQLHVTLTQK QEEIASLKER NVQLKELASR TRHLASVLDK LMITQSRDCG 250
AAAEPFLLKA KAKRSLEELV SAAGQDCAEV DAILREISER CDEALQSRDP 300
KRPRLLPEPA NTDTRPGNLH GAFRGLRTDC SRSALNLSHS ELEEGGSFST 350
RIRSHSTIRT LAFPQGNAFT IRTANGGYKF RWVPS 385
Length:385
Mass (Da):41,720
Last modified:July 13, 2010 - v1
Checksum:iD52A35B926E75723
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR854393 mRNA. Translation: CCA89438.1.
AC091977 Genomic DNA. No translation available.
CCDSiCCDS54853.1.
RefSeqiNP_001177716.1. NM_001190787.1.
UniGeneiHs.394578.

Genome annotation databases

EnsembliENST00000513312; ENSP00000426359; ENSG00000234602.
GeneIDi345643.
KEGGihsa:345643.
UCSCiuc021xyp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR854393 mRNA. Translation: CCA89438.1 .
AC091977 Genomic DNA. No translation available.
CCDSi CCDS54853.1.
RefSeqi NP_001177716.1. NM_001190787.1.
UniGenei Hs.394578.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BRY X-ray 2.89 B 173-245 [» ]
ProteinModelPortali D6RGH6.
SMRi D6RGH6. Positions 176-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi D6RGH6. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000513312 ; ENSP00000426359 ; ENSG00000234602 .
GeneIDi 345643.
KEGGi hsa:345643.
UCSCi uc021xyp.1. human.

Organism-specific databases

CTDi 345643.
GeneCardsi GC05M054521.
HGNCi HGNC:40050. MCIDAS.
HPAi HPA049981.
MIMi 614086. gene.
neXtProti NX_D6RGH6.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000133078.
KOi K10749.
OMAi GYKFRWV.
PhylomeDBi D6RGH6.

Miscellaneous databases

GenomeRNAii 345643.
NextBioi 98889.
PROi D6RGH6.
SOURCEi Search...

Family and domain databases

InterProi IPR022786. Geminin/Multicilin.
IPR029699. Multicilin/Idas.
[Graphical view ]
PANTHERi PTHR13372:SF3. PTHR13372:SF3. 1 hit.
Pfami PF07412. Geminin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression."
    Pefani D.E., Dimaki M., Spella M., Karantzelis N., Mitsiki E., Kyrousi C., Symeonidou I.E., Perrakis A., Taraviras S., Lygerou Z.
    J. Biol. Chem. 286:23234-23246(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GMNN, HOMODIMERIZATION, SUBUNIT, DEVELOPMENTAL STAGE.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing."
    Caillat C., Pefani E.D., Gillespie P.J., Taraviras S., Blow J.J., Lygerou Z., Perrakis A.
    J. Biol. Chem. 288:31624-31634(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 173-245 IN COMPLEX WITH GMNN, FUNCTION, COILED-COIL DOMAIN, SUBUNIT.

Entry informationi

Entry nameiMCIN_HUMAN
AccessioniPrimary (citable) accession number: D6RGH6
Secondary accession number(s): C9JGY3, D6R920, F8KGQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 13, 2010
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Was named Idas in reference to the cousin of the Gemini in ancient Greek mythology (1 Publication).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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