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Protein
Submitted name:

Amphiregulin

Gene

AREG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
AmphiregulinImported
Gene namesi
Name:AREGImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:651. AREG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 221HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500308757927 – 274Sequence analysisAdd BLAST248

Proteomic databases

MaxQBiD6RFX5.
PaxDbiD6RFX5.
PeptideAtlasiD6RFX5.
PRIDEiD6RFX5.

Expressioni

Gene expression databases

BgeeiENSG00000109321.
ExpressionAtlasiD6RFX5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370227.

Structurei

3D structure databases

ProteinModelPortaliD6RFX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 182EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXZG. Eukaryota.
ENOG4112CXY. LUCA.
GeneTreeiENSGT00530000063708.
HOGENOMiHOG000034038.
OrthoDBiEOG091G0XMN.
PhylomeDBiD6RFX5.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6RFX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE
60 70 80 90 100
VTSRSEMSSG SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD
110 120 130 140 150
SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF
160 170 180 190 200
QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSKIA
210 220 230 240 250
LAAIAAFMSA VILTAVAVIT VQISHWSHCQ VIAINDESVL FPVDHKTMDP
260 270
FCYDGFKLSI VTFYAISVYK GARR
Length:274
Mass (Da):30,260
Last modified:July 13, 2010 - v1
Checksum:i993E1DE4A3FCBC9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021180 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000502307; ENSP00000421414; ENSG00000109321.
UCSCiuc062xhr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021180 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RFX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370227.

Proteomic databases

MaxQBiD6RFX5.
PaxDbiD6RFX5.
PeptideAtlasiD6RFX5.
PRIDEiD6RFX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502307; ENSP00000421414; ENSG00000109321.
UCSCiuc062xhr.1. human.

Organism-specific databases

HGNCiHGNC:651. AREG.
OpenTargetsiENSG00000109321.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXZG. Eukaryota.
ENOG4112CXY. LUCA.
GeneTreeiENSGT00530000063708.
HOGENOMiHOG000034038.
OrthoDBiEOG091G0XMN.
PhylomeDBiD6RFX5.

Gene expression databases

BgeeiENSG00000109321.
ExpressionAtlasiD6RFX5. baseline and differential.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6RFX5_HUMAN
AccessioniPrimary (citable) accession number: D6RFX5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.