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Protein
Submitted name:

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. misfolded protein binding Source: MGI
  2. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. cell morphogenesis Source: MGI
  2. central nervous system myelin maintenance Source: MGI
  3. chaperone-mediated protein complex assembly Source: MGI
  4. chaperone-mediated protein folding Source: MGI
  5. intrinsic apoptotic signaling pathway Source: MGI
  6. microglial cell activation Source: MGI
  7. microglial cell proliferation Source: MGI
  8. negative regulation of beta-amyloid formation Source: MGI
  9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  10. negative regulation of protein homooligomerization Source: MGI
  11. positive regulation of apoptotic process Source: MGI
  12. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  13. positive regulation of neurofibrillary tangle assembly Source: MGI
  14. positive regulation of neuron death Source: MGI
  15. positive regulation of NF-kappaB transcription factor activity Source: MGI
  16. positive regulation of nitric oxide biosynthetic process Source: MGI
  17. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  18. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  19. positive regulation of tau-protein kinase activity Source: MGI
  20. positive regulation of tumor necrosis factor production Source: MGI
  21. protein import Source: MGI
  22. protein stabilization Source: MGI
  23. regulation of beta-amyloid clearance Source: MGI
  24. regulation of neuronal signal transduction Source: MGI
  25. regulation of neuron death Source: MGI
  26. response to misfolded protein Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ClusterinImported
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

GO - Cellular componenti

  1. apical dendrite Source: MGI
  2. blood microparticle Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular matrix Source: MGI
  5. extracellular space Source: MGI
  6. extracellular vesicular exosome Source: MGI
  7. mitochondrion Source: MGI
  8. neurofibrillary tangle Source: MGI
  9. perinuclear region of cytoplasm Source: MGI
  10. spherical high-density lipoprotein particle Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD6RFP9.
ExpressionAtlasiD6RFP9. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063668.

Sequencei

Sequence statusi: Complete.

D6RFP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30 
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QGRTVHSRE
Length:39
Mass (Da):4,424
Last modified:July 13, 2010 - v1
Checksum:iEFDC1984574EE677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126444 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000138665; ENSMUSP00000121056; ENSMUSG00000022037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126444 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000138665; ENSMUSP00000121056; ENSMUSG00000022037.

Organism-specific databases

MGIiMGI:88423. Clu.

Phylogenomic databases

GeneTreeiENSGT00530000063668.

Miscellaneous databases

ChiTaRSiClu. mouse.
NextBioi35552195.
SOURCEiSearch...

Gene expression databases

BgeeiD6RFP9.
ExpressionAtlasiD6RFP9. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD6RFP9_MOUSE
AccessioniPrimary (citable) accession number: D6RFP9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 4, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.