ID   D6RF86_HUMAN            Unreviewed;       608 AA.
AC   D6RF86;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=Cadherin 6 {ECO:0000313|Ensembl:ENSP00000424843.1};
GN   Name=CDH6 {ECO:0000313|Ensembl:ENSP00000424843.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424843.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424843.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000424843.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC091898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC113386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6RF86; -.
DR   SMR; D6RF86; -.
DR   MassIVE; D6RF86; -.
DR   PeptideAtlas; D6RF86; -.
DR   ProteomicsDB; 14492; -.
DR   Antibodypedia; 2354; 500 antibodies from 36 providers.
DR   Ensembl; ENST00000514738.5; ENSP00000424843.1; ENSG00000113361.13.
DR   UCSC; uc063cqv.1; human.
DR   HGNC; HGNC:1765; CDH6.
DR   VEuPathDB; HostDB:ENSG00000113361; -.
DR   GeneTree; ENSGT00940000154673; -.
DR   HOGENOM; CLU_005284_4_3_1; -.
DR   ChiTaRS; CDH6; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113361; Expressed in type B pancreatic cell and 177 other cell types or tissues.
DR   ExpressionAtlas; D6RF86; baseline and differential.
DR   GO; GO:0030054; C:cell junction; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 5.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   PANTHER; PTHR24027:SF322; CADHERIN-6; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:D6RF86,
KW   ECO:0007829|MaxQB:D6RF86};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        555..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..104
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          105..213
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          214..328
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          329..433
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          433..555
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          204..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   608 AA;  67403 MW;  BEF5A4C6C5644583 CRC64;
     MWNQFFLLEE YTGSDYQYVG KLHSDQDRGD GSLKYILSGD GAGDLFIINE NTGDIQATKR
     LDREEKPVYI LRAQAINRRT GRPVEPESEF IIKIHDINDN EPIFTKEVYT ATVPEMSDVG
     TFVVQVTATD ADDPTYGNSA KVVYSILQGQ PYFSVESETG IIKTALLNMD RENREQYQVV
     IQAKDMGGQM GGLSGTTTVN ITLTDVNDNP PRFPQSTYQF KTPESSPPGT PIGRIKASDA
     DVGENAEIEY SITDGEGLDM FDVITDQETQ EGIITVKKLL DFEKKKVYTL KVEASNPYVE
     PRFLYLGPFK DSATVRIVVE DVDEPPVFSK LAYILQIRED AQINTTIGSV TAQDPDAARN
     PVKYSVDRHT DMDRIFNIDS GNGSIFTSKL LDRETLLWHN ITVIATEINN PKQSSRVPLY
     IKVLDVNDNA PEFAEFYETF VCEKAKADQL IQTLHAVDKD DPYSGHQFSF SLAPEAASGS
     NFTIQDNKDN TAGILTRKNG YNRHEMSTYL LPVVISDNDY PVQSSTGTVT VRVCACDHHG
     NMQSCHAEAL IHPTGLSTGA LVAILLCIVI LLGKLVLPAS YLPMVRGSHC YCDTLDLSAS
     PIKAYSLI
//