D6RF86 (D6RF86_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cadherin-6 Ensembl ENSP00000424843

Gene names

Name:

CDH6 Ensembl ENSP00000424843

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000424843

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	608 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000424843

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS020894
Cellular component	Membrane
Domain	Repeat SAAS SAAS020894 Transmembrane SAAS SAAS020894
Ligand	Calcium RuleBase RU000484 SAAS SAAS020894
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D6RF86 [UniParc]. Last modified July 13, 2010. Version 1. Checksum: BEF5A4C6C5644583	FASTA	608	67,403
	10 20 30 40 50 60 MWNQFFLLEE YTGSDYQYVG KLHSDQDRGD GSLKYILSGD GAGDLFIINE NTGDIQATKR 70 80 90 100 110 120 LDREEKPVYI LRAQAINRRT GRPVEPESEF IIKIHDINDN EPIFTKEVYT ATVPEMSDVG 130 140 150 160 170 180 TFVVQVTATD ADDPTYGNSA KVVYSILQGQ PYFSVESETG IIKTALLNMD RENREQYQVV 190 200 210 220 230 240 IQAKDMGGQM GGLSGTTTVN ITLTDVNDNP PRFPQSTYQF KTPESSPPGT PIGRIKASDA 250 260 270 280 290 300 DVGENAEIEY SITDGEGLDM FDVITDQETQ EGIITVKKLL DFEKKKVYTL KVEASNPYVE 310 320 330 340 350 360 PRFLYLGPFK DSATVRIVVE DVDEPPVFSK LAYILQIRED AQINTTIGSV TAQDPDAARN 370 380 390 400 410 420 PVKYSVDRHT DMDRIFNIDS GNGSIFTSKL LDRETLLWHN ITVIATEINN PKQSSRVPLY 430 440 450 460 470 480 IKVLDVNDNA PEFAEFYETF VCEKAKADQL IQTLHAVDKD DPYSGHQFSF SLAPEAASGS 490 500 510 520 530 540 NFTIQDNKDN TAGILTRKNG YNRHEMSTYL LPVVISDNDY PVQSSTGTVT VRVCACDHHG 550 560 570 580 590 600 NMQSCHAEAL IHPTGLSTGA LVAILLCIVI LLGKLVLPAS YLPMVRGSHC YCDTLDLSAS PIKAYSLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC091898 Genomic DNA. No translation available. AC113386 Genomic DNA. No translation available.
IPI	IPI00217314.
3D structure databases
ProteinModelPortal	D6RF86.
SMR	D6RF86. Positions 1-534.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000514738; ENSP00000424843; ENSG00000113361.
Organism-specific databases
HGNC	HGNC:1765. CDH6.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000231252.
Gene expression databases
ArrayExpress	D6RF86.
Bgee	D6RF86.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35494405.

Entry information

Entry name

D6RF86_HUMAN

Accession

Primary (citable) accession number: D6RF86

Entry history

Integrated into UniProtKB/TrEMBL:	July 13, 2010
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.