Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cadherin-6

Gene

CDH6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cadherin-6Imported
Gene namesi
Name:CDH6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113361.12
HGNCiHGNC:1765 CDH6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei555 – 577HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113361

PTM / Processingi

Proteomic databases

PeptideAtlasiD6RF86
PRIDEiD6RF86

Expressioni

Gene expression databases

BgeeiENSG00000113361
ExpressionAtlasiD6RF86 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6RF86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 102CAInterPro annotationAdd BLAST82
Domaini126 – 211CAInterPro annotationAdd BLAST86
Domaini235 – 327CAInterPro annotationAdd BLAST93
Domaini350 – 431CAInterPro annotationAdd BLAST82
Domaini454 – 541CAInterPro annotationAdd BLAST88

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits

Sequencei

Sequence statusi: Complete.

D6RF86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNQFFLLEE YTGSDYQYVG KLHSDQDRGD GSLKYILSGD GAGDLFIINE
60 70 80 90 100
NTGDIQATKR LDREEKPVYI LRAQAINRRT GRPVEPESEF IIKIHDINDN
110 120 130 140 150
EPIFTKEVYT ATVPEMSDVG TFVVQVTATD ADDPTYGNSA KVVYSILQGQ
160 170 180 190 200
PYFSVESETG IIKTALLNMD RENREQYQVV IQAKDMGGQM GGLSGTTTVN
210 220 230 240 250
ITLTDVNDNP PRFPQSTYQF KTPESSPPGT PIGRIKASDA DVGENAEIEY
260 270 280 290 300
SITDGEGLDM FDVITDQETQ EGIITVKKLL DFEKKKVYTL KVEASNPYVE
310 320 330 340 350
PRFLYLGPFK DSATVRIVVE DVDEPPVFSK LAYILQIRED AQINTTIGSV
360 370 380 390 400
TAQDPDAARN PVKYSVDRHT DMDRIFNIDS GNGSIFTSKL LDRETLLWHN
410 420 430 440 450
ITVIATEINN PKQSSRVPLY IKVLDVNDNA PEFAEFYETF VCEKAKADQL
460 470 480 490 500
IQTLHAVDKD DPYSGHQFSF SLAPEAASGS NFTIQDNKDN TAGILTRKNG
510 520 530 540 550
YNRHEMSTYL LPVVISDNDY PVQSSTGTVT VRVCACDHHG NMQSCHAEAL
560 570 580 590 600
IHPTGLSTGA LVAILLCIVI LLGKLVLPAS YLPMVRGSHC YCDTLDLSAS

PIKAYSLI
Length:608
Mass (Da):67,403
Last modified:July 13, 2010 - v1
Checksum:iBEF5A4C6C5644583
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091898 Genomic DNA No translation available.
AC113386 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000514738; ENSP00000424843; ENSG00000113361
UCSCiuc063cqv.1 human

Similar proteinsi

Entry informationi

Entry nameiD6RF86_HUMAN
AccessioniPrimary (citable) accession number: D6RF86
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health