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Protein

Protein Wnt

Gene

WNT8A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotationSAAS annotation
Biological processWnt signaling pathwayUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WntUniRule annotation
Gene namesi
Name:WNT8AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000061492.11.
HGNCiHGNC:12788. WNT8A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrixSAAS annotation, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000061492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500308776723 – 369Protein WntSequence analysisAdd BLAST347

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiD6RF47.
PeptideAtlasiD6RF47.
PRIDEiD6RF47.

Expressioni

Gene expression databases

BgeeiENSG00000061492.
ExpressionAtlasiD6RF47. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliD6RF47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
OMAiSAWSVNN.
OrthoDBiEOG091G0B1B.
PhylomeDBiD6RF47.

Family and domain databases

InterProiView protein in InterPro
IPR034312. Protein_Wnt-8A/8C.
IPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF92. PTHR12027:SF92. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
PRINTSiPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.
PROSITEiView protein in PROSITE
PS00246. WNT1. 1 hit.

Sequencei

Sequence statusi: Complete.

D6RF47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCCIQCLCL VSPFPTLTPC QGGPHCLIPI HLCLTFSLFG RSVNNFLITG
60 70 80 90 100
PKAYLTYTTS VALGAQSGIE ECKFQFAWER WNCPENALQL STHNRLRSAT
110 120 130 140 150
RETSFIHAIS SAGVMYIITK NCSMGDFENC GCDGSNNGKT GGHGWIWGGC
160 170 180 190 200
SDNVEFGERI SKLFVDSLEK GKDARALMNL HNNRAGRLAV RATMKRTCKC
210 220 230 240 250
HGISGSCSIQ TCWLQLAEFR EMGDYLKAKY DQALKIEMDK RQLRAGNSAE
260 270 280 290 300
GHWVPAEAFL PSAEAELIFL EESPDYCTCN SSLGIYGTEG RECLQNSHNT
310 320 330 340 350
SRWERRSCGR LCTECGLQVE ERKTEVISSC NCKFQWCCTV KCDQCRHVVS
360
KYYCARSPGS AQSLGKGSA
Length:369
Mass (Da):40,892
Last modified:July 13, 2010 - v1
Checksum:iAF8F9A9B71878843
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113382 Genomic DNA. No translation available.
RefSeqiNP_001287868.1. NM_001300939.1.
UniGeneiHs.591274.

Genome annotation databases

EnsembliENST00000506684; ENSP00000426653; ENSG00000061492.
GeneIDi7478.
UCSCiuc011cyk.2. human.

Similar proteinsi

Entry informationi

Entry nameiD6RF47_HUMAN
AccessioniPrimary (citable) accession number: D6RF47
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 25, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported