ID   D6REX0_HUMAN            Unreviewed;       232 AA.
AC   D6REX0;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif 12 {ECO:0000313|Ensembl:ENSP00000421638.1};
GN   Name=ADAMTS12 {ECO:0000313|Ensembl:ENSP00000421638.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421638.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421638.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421638.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC008880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC034232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC139777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001311440.1; NM_001324511.1.
DR   AlphaFoldDB; D6REX0; -.
DR   MassIVE; D6REX0; -.
DR   PeptideAtlas; D6REX0; -.
DR   ProteomicsDB; 14389; -.
DR   Antibodypedia; 22743; 158 antibodies from 23 providers.
DR   DNASU; 81792; -.
DR   Ensembl; ENST00000515401.1; ENSP00000421638.1; ENSG00000151388.11.
DR   GeneID; 81792; -.
DR   UCSC; uc003jib.1; human.
DR   CTD; 81792; -.
DR   HGNC; HGNC:14605; ADAMTS12.
DR   VEuPathDB; HostDB:ENSG00000151388; -.
DR   GeneTree; ENSGT00940000155855; -.
DR   HOGENOM; CLU_104239_0_0_1; -.
DR   OrthoDB; 4734834at2759; -.
DR   BioGRID-ORCS; 81792; 14 hits in 1144 CRISPR screens.
DR   ChiTaRS; ADAMTS12; human.
DR   GenomeRNAi; 81792; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000151388; Expressed in adrenal tissue and 121 other cell types or tissues.
DR   ExpressionAtlas; D6REX0; baseline and differential.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Proteomics identification {ECO:0007829|MaxQB:D6REX0,
KW   ECO:0007829|PeptideAtlas:D6REX0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..232
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003087765"
FT   DOMAIN          54..145
FT                   /note="Peptidase M12B propeptide"
FT                   /evidence="ECO:0000259|Pfam:PF01562"
SQ   SEQUENCE   232 AA;  26426 MW;  4D9BEBF1FBCB40E8 CRC64;
     MPCAQRSWLA NLSVVAQLLN FGALCYGRQP QPGPVRFPDR RQEHFIKGLP EYHVVGPVRV
     DASGHFLSYG LHYPITSSRR KRDLDGSEDW VYYRISHEEK DLFFNLTVNQ GFLSNSYIME
     KRYGNLSHVK MMASSAPLCH LSGTVLQQGT RVGTAALSAC HGLTGFFQLP HGDFFIEPVK
     KHPLVEGGYH PHIVYRRQKV PETKEPTCGL KGIVTHMSSW VEESVLFFWL FY
//