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Protein
Submitted name:

Nephronectin

Gene

NPNT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: Ensembl
  2. cell-cell adhesion mediated by integrin Source: Ensembl
  3. cell-matrix adhesion Source: Ensembl
  4. cellular response to tumor necrosis factor Source: Ensembl
  5. establishment of protein localization Source: Ensembl
  6. extracellular matrix organization Source: Ensembl
  7. pilomotor reflex Source: Ensembl
  8. positive regulation of alkaline phosphatase activity Source: Ensembl
  9. positive regulation of cell-substrate adhesion Source: Ensembl
  10. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  11. positive regulation of osteoblast differentiation Source: Ensembl
  12. positive regulation of smooth muscle contraction Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
  14. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NephronectinImported
Gene namesi
Name:NPNTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:27405. NPNT.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. integrin alpha8-beta1 complex Source: Ensembl
  3. smooth muscle contractile fiber Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD6RE63.
ExpressionAtlasiD6RE63. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD6RE63.
SMRiD6RE63. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00770000120465.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.

Sequencei

Sequence statusi: Fragment.

D6RE63-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTYGSYKCY CLNGYMLMPD GSCSSALTCS MANCQYGCDV VKGQIRCQCP
60
SPGLQLAPDG R
Length:61
Mass (Da):6,556
Last modified:July 13, 2010 - v1
Checksum:i1AF1395B80A24DA6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei61 – 611Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093782 Genomic DNA. No translation available.
AC109361 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000504304; ENSP00000426951; ENSG00000168743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093782 Genomic DNA. No translation available.
AC109361 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RE63.
SMRiD6RE63. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504304; ENSP00000426951; ENSG00000168743.

Organism-specific databases

HGNCiHGNC:27405. NPNT.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00770000120465.

Miscellaneous databases

ChiTaRSiNPNT. human.
NextBioi35494152.

Gene expression databases

BgeeiD6RE63.
ExpressionAtlasiD6RE63. baseline and differential.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiD6RE63_HUMAN
AccessioniPrimary (citable) accession number: D6RE63
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: January 7, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.