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Protein
Submitted name:

Calnexin

Gene

CANX

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
CalnexinImported
Gene namesi
Name:CANXImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1473. CANX.

Subcellular locationi

  • Endoplasmic reticulum SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500512671421 – 168UniRule annotationAdd BLAST148

Proteomic databases

MaxQBiD6RDP7.
PaxDbiD6RDP7.
PeptideAtlasiD6RDP7.
PRIDEiD6RDP7.

Expressioni

Gene expression databases

BgeeiENSG00000127022.
ExpressionAtlasiD6RDP7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000247461.

Structurei

3D structure databases

ProteinModelPortaliD6RDP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calreticulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG0675. Eukaryota.
ENOG410XP7T. LUCA.
GeneTreeiENSGT00430000030841.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D6RDP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKWLLCML LVLGTAIVEA HDGHDDDVID IEDDLDDVIE EVEDSKPDTT
60 70 80 90 100
APPSSPKVTY KAPVPTGEVY FADSFDRGTL SGWILSKAKK DDTDDEIAKY
110 120 130 140 150
DGKWEVEEMK ESKLPGDKGL VLMSRAKHHA ISAKLNKPFL FDTKPLIVQY
160
EVNFQNGIEC GGAYVKLL
Length:168
Mass (Da):18,658
Last modified:July 13, 2010 - v1
Checksum:i7EF3690919B4300E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei168Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113426 Genomic DNA. No translation available.
AC136604 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000502498; ENSP00000425246; ENSG00000127022.
UCSCiuc063kpb.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113426 Genomic DNA. No translation available.
AC136604 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RDP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000247461.

Proteomic databases

MaxQBiD6RDP7.
PaxDbiD6RDP7.
PeptideAtlasiD6RDP7.
PRIDEiD6RDP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502498; ENSP00000425246; ENSG00000127022.
UCSCiuc063kpb.1. human.

Organism-specific databases

HGNCiHGNC:1473. CANX.
OpenTargetsiENSG00000127022.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0675. Eukaryota.
ENOG410XP7T. LUCA.
GeneTreeiENSGT00430000030841.

Miscellaneous databases

ChiTaRSiCANX. human.

Gene expression databases

BgeeiENSG00000127022.
ExpressionAtlasiD6RDP7. baseline and differential.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6RDP7_HUMAN
AccessioniPrimary (citable) accession number: D6RDP7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.