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D6RDP7

- D6RDP7_HUMAN

UniProt

D6RDP7 - D6RDP7_HUMAN

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Protein
Submitted name:

Calnexin

Gene

CANX

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. aging Source: Ensembl
  2. chaperone-mediated protein folding Source: Ensembl
  3. clathrin-mediated endocytosis Source: Ensembl
  4. synaptic vesicle endocytosis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
CalnexinImported
Gene namesi
Name:CANXImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1473. CANX.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. dendrite cytoplasm Source: Ensembl
  3. dendritic spine Source: Ensembl
  4. endoplasmic reticulum Source: HPA
  5. integral component of membrane Source: Ensembl
  6. neuronal cell body Source: Ensembl
  7. protein complex Source: Ensembl
  8. ribosome Source: Ensembl
  9. rough endoplasmic reticulum Source: Ensembl
  10. smooth endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

Expressioni

Gene expression databases

BgeeiD6RDP7.
ExpressionAtlasiD6RDP7. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliD6RDP7.
SMRiD6RDP7. Positions 60-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calreticulin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00430000030841.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D6RDP7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGKWLLCML LVLGTAIVEA HDGHDDDVID IEDDLDDVIE EVEDSKPDTT
60 70 80 90 100
APPSSPKVTY KAPVPTGEVY FADSFDRGTL SGWILSKAKK DDTDDEIAKY
110 120 130 140 150
DGKWEVEEMK ESKLPGDKGL VLMSRAKHHA ISAKLNKPFL FDTKPLIVQY
160
EVNFQNGIEC GGAYVKLL
Length:168
Mass (Da):18,658
Last modified:July 13, 2010 - v1
Checksum:i7EF3690919B4300E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei168 – 1681Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113426 Genomic DNA. No translation available.
AC136604 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000502498; ENSP00000425246; ENSG00000127022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113426 Genomic DNA. No translation available.
AC136604 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali D6RDP7.
SMRi D6RDP7. Positions 60-168.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi D6RDP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000502498 ; ENSP00000425246 ; ENSG00000127022 .

Organism-specific databases

HGNCi HGNC:1473. CANX.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00430000030841.

Miscellaneous databases

ChiTaRSi CANX. human.
NextBioi 35494080.

Gene expression databases

Bgeei D6RDP7.
ExpressionAtlasi D6RDP7. baseline and differential.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR013320. ConA-like_dom.
[Graphical view ]
PANTHERi PTHR11073. PTHR11073. 1 hit.
Pfami PF00262. Calreticulin. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00803. CALRETICULIN_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiD6RDP7_HUMAN
AccessioniPrimary (citable) accession number: D6RDP7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 26, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3