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D6RDN7

- D6RDN7_HUMAN

UniProt

D6RDN7 - D6RDN7_HUMAN

Protein
Submitted name:

Mothers against decapentaplegic homolog 1

Gene

SMAD1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. bone development Source: Ensembl
    2. cardiac muscle cell proliferation Source: Ensembl
    3. cartilage development Source: Ensembl
    4. cellular response to BMP stimulus Source: Ensembl
    5. cellular response to organic cyclic compound Source: Ensembl
    6. gamete generation Source: Ensembl
    7. hindbrain development Source: Ensembl
    8. homeostatic process Source: Ensembl
    9. inflammatory response Source: Ensembl
    10. kidney development Source: Ensembl
    11. MAPK cascade Source: Ensembl
    12. mesodermal cell fate commitment Source: Ensembl
    13. midbrain development Source: Ensembl
    14. negative regulation of cell proliferation Source: Ensembl
    15. negative regulation of muscle cell apoptotic process Source: Ensembl
    16. osteoblast fate commitment Source: Ensembl
    17. positive regulation of cartilage development Source: Ensembl
    18. positive regulation of dendrite morphogenesis Source: Ensembl
    19. positive regulation of osteoblast differentiation Source: Ensembl
    20. positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: Ensembl
    21. protein phosphorylation Source: Ensembl
    22. response to drug Source: Ensembl
    23. response to organonitrogen compound Source: Ensembl
    24. transcription, DNA-templated Source: UniProtKB-KW
    25. transforming growth factor beta receptor signaling pathway Source: InterPro
    26. ureteric bud development Source: Ensembl
    27. wound healing Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mothers against decapentaplegic homolog 1Imported
    Gene namesi
    Name:SMAD1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:6767. SMAD1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-KW
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiD6RDN7.
    BgeeiD6RDN7.

    Structurei

    3D structure databases

    ProteinModelPortaliD6RDN7.
    SMRiD6RDN7. Positions 9-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000198838.

    Family and domain databases

    Gene3Di3.90.520.10. 1 hit.
    InterProiIPR013790. Dwarfin.
    IPR003619. MAD_homology1_Dwarfin-type.
    IPR013019. MAD_homology_MH1.
    [Graphical view]
    PANTHERiPTHR13703. PTHR13703. 1 hit.
    PfamiPF03165. MH1. 1 hit.
    [Graphical view]
    SMARTiSM00523. DWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF56366. SSF56366. 1 hit.
    PROSITEiPS51075. MH1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D6RDN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE    50
    LEKALSCPGQ PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH 100
    HELKPLECCE FP 112
    Length:112
    Mass (Da):12,826
    Last modified:July 13, 2010 - v1
    Checksum:i854A013F6E86639B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei112 – 1121Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093796 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000514831; ENSP00000425270; ENSG00000170365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093796 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D6RDN7.
    SMRi D6RDN7. Positions 9-112.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000514831 ; ENSP00000425270 ; ENSG00000170365 .

    Organism-specific databases

    HGNCi HGNC:6767. SMAD1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000198838.

    Miscellaneous databases

    NextBioi 35494073.

    Gene expression databases

    ArrayExpressi D6RDN7.
    Bgeei D6RDN7.

    Family and domain databases

    Gene3Di 3.90.520.10. 1 hit.
    InterProi IPR013790. Dwarfin.
    IPR003619. MAD_homology1_Dwarfin-type.
    IPR013019. MAD_homology_MH1.
    [Graphical view ]
    PANTHERi PTHR13703. PTHR13703. 1 hit.
    Pfami PF03165. MH1. 1 hit.
    [Graphical view ]
    SMARTi SM00523. DWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56366. SSF56366. 1 hit.
    PROSITEi PS51075. MH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiD6RDN7_HUMAN
    AccessioniPrimary (citable) accession number: D6RDN7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3