ID D6RCL5_HUMAN Unreviewed; 240 AA. AC D6RCL5; DT 13-JUL-2010, integrated into UniProtKB/TrEMBL. DT 13-JUL-2010, sequence version 1. DT 27-MAR-2024, entry version 81. DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 4 {ECO:0000313|Ensembl:ENSP00000427191.1}; DE Flags: Fragment; GN Name=HERC4 {ECO:0000313|Ensembl:ENSP00000427191.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427191.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000427191.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000427191.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC024258; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL133551; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL356741; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; D6RCL5; -. DR SMR; D6RCL5; -. DR MassIVE; D6RCL5; -. DR MaxQB; D6RCL5; -. DR PeptideAtlas; D6RCL5; -. DR ProteomicsDB; 13929; -. DR Antibodypedia; 28396; 197 antibodies from 27 providers. DR Ensembl; ENST00000513996.5; ENSP00000427191.1; ENSG00000148634.16. DR UCSC; uc057tpv.1; human. DR HGNC; HGNC:24521; HERC4. DR VEuPathDB; HostDB:ENSG00000148634; -. DR GeneTree; ENSGT00940000158924; -. DR HOGENOM; CLU_005210_2_3_1; -. DR ChiTaRS; HERC4; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000148634; Expressed in adrenal tissue and 185 other cell types or tissues. DR ExpressionAtlas; D6RCL5; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0001650; C:fibrillar center; IDA:HPA. DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2. DR InterPro; IPR009091; RCC1/BLIP-II. DR InterPro; IPR000408; Reg_chr_condens. DR PANTHER; PTHR22870:SF24; BTB DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1. DR Pfam; PF00415; RCC1; 4. DR PRINTS; PR00633; RCCNDNSATION. DR SUPFAM; SSF50985; RCC1/BLIP-II; 1. DR PROSITE; PS00626; RCC1_2; 2. DR PROSITE; PS50012; RCC1_3; 4. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:D6RCL5, KW ECO:0007829|MaxQB:D6RCL5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT REPEAT 1..52 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT REPEAT 53..102 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT REPEAT 103..179 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT REPEAT 180..232 FT /note="RCC1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235" FT NON_TER 240 FT /evidence="ECO:0000313|Ensembl:ENSP00000427191.1" SQ SEQUENCE 240 AA; 25895 MW; 188C67596F9C9883 CRC64; MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKRVRDVG CGLRHTVFVL DDGTVYTCGC NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLVG SEECIRVPSC FPKIMCVDSL VRICSGLSYG RIRNIKSLSD IQIVQVACGY YHSLALSKAS EVFCWGQNKY GQLGLGTDCK KQTSPQLLKS LLGIPFMQVA AGGAHSFVLT LSGAIFGWGR //