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Protein
Submitted name:

Nicastrin

Gene

Ncstn

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. endopeptidase activity Source: MGI

GO - Biological processi

  1. beta-amyloid metabolic process Source: MGI
  2. epithelial cell proliferation Source: MGI
  3. membrane protein ectodomain proteolysis Source: MGI
  4. myeloid cell homeostasis Source: MGI
  5. positive regulation of catalytic activity Source: MGI
  6. protein processing Source: MGI
  7. T cell proliferation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NicastrinImported
Gene namesi
Name:NcstnImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1891700. Ncstn.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. focal adhesion Source: MGI
  4. Golgi apparatus Source: MGI
  5. integral component of plasma membrane Source: MGI
  6. lysosomal membrane Source: MGI
  7. membrane Source: MGI
  8. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD6RCJ2.
ExpressionAtlasiD6RCJ2. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000014633.
HOGENOMiHOG000185997.

Family and domain databases

InterProiIPR008710. Nicastrin.
[Graphical view]
PANTHERiPTHR21092. PTHR21092. 1 hit.

Sequencei

Sequence statusi: Complete.

D6RCJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTRGGSGP DPGSRGLLLL SFSVVLAGLC GGNSVERKIY IPLNKTAPCV
60
RLLNATHQIG CQ
Length:62
Mass (Da):6,410
Last modified:July 13, 2010 - v1
Checksum:iD1E33F6B0B6F1121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158930 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000140643; ENSMUSP00000119128; ENSMUSG00000003458.
ENSMUST00000146137; ENSMUSP00000120663; ENSMUSG00000003458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158930 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000140643; ENSMUSP00000119128; ENSMUSG00000003458.
ENSMUST00000146137; ENSMUSP00000120663; ENSMUSG00000003458.

Organism-specific databases

MGIiMGI:1891700. Ncstn.

Phylogenomic databases

GeneTreeiENSGT00390000014633.
HOGENOMiHOG000185997.

Miscellaneous databases

NextBioi35551869.
SOURCEiSearch...

Gene expression databases

BgeeiD6RCJ2.
ExpressionAtlasiD6RCJ2. baseline and differential.

Family and domain databases

InterProiIPR008710. Nicastrin.
[Graphical view]
PANTHERiPTHR21092. PTHR21092. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiD6RCJ2_MOUSE
AccessioniPrimary (citable) accession number: D6RCJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 1, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.