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D6RCE4

- D6RCE4_HUMAN

UniProt

D6RCE4 - D6RCE4_HUMAN

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Protein
Submitted name:

Protocadherin Fat 1

Gene

FAT1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. actin filament organization Source: Ensembl
  2. establishment or maintenance of cell polarity Source: Ensembl
  3. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  4. single organismal cell-cell adhesion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin Fat 1Imported
Gene namesi
Name:FAT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:3595. FAT1.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: Ensembl
  2. filopodium Source: Ensembl
  3. lamellipodium Source: Ensembl
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD6RCE4.
ExpressionAtlasiD6RCE4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD6RCE4.
SMRiD6RCE4. Positions 29-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.

Family and domain databases

Gene3Di2.60.40.60. 3 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view]
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS50268. CADHERIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D6RCE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRHLALLLL LLLLFQHFGD SDGSQRLEQT PLQFTHLEYN VTVQENSAAK
60 70 80 90 100
TYVGHPVKMG VYITHPAWEV RYKIVSGDSE NLFKAEEYIL GDFCFLRIRT
110 120 130 140 150
KGGNTAILNR EVKDHYTLIV KALEKNTNVE ARTKVRVQVL DTNDLRPLFS
160 170 180 190 200
PTSYSVSLPE NTAIRTSIAR VSATDADIGT NGEFYYSFKD RTDMFAIHPT
210 220 230 240 250
SGVIVLTGRL DYLETKLYEM EILAADRGMK LYGSSGISSM AKLTVHIEQA
260 270 280 290 300
NECAPVITAV TLSPSELDRD PAYAIVTVDD CDQGANGDIA SLSIVAGDLL
310 320 330 340 350
QQFRTVRSFP GSKEYKVKAI GGIDWDSHPF GYNLTLQAKD KGTPPQFSSV
360 370 380 390 400
KVIHVTSPQF KAGPVKFEKD VYRAEISEFA PPNTPVVMVK AIPAYSHLRY
410 420 430 440 450
VFKSTPGKAK FSLNYNTGLI SILEPVKRQQ AAHFELEVTT SDRKASTKVL
460 470 480
VKVLGANSNP PEFTQTAYKA AFDENVPIGT TVMSLSAV
Length:488
Mass (Da):53,921
Last modified:July 13, 2010 - v1
Checksum:i70A24EAA1C0692F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei488 – 4881Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107050 Genomic DNA. No translation available.
AC110761 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000509647; ENSP00000423736; ENSG00000083857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107050 Genomic DNA. No translation available.
AC110761 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali D6RCE4.
SMRi D6RCE4. Positions 29-488.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000509647 ; ENSP00000423736 ; ENSG00000083857 .

Organism-specific databases

HGNCi HGNC:3595. FAT1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118805.
HOGENOMi HOG000046499.

Miscellaneous databases

ChiTaRSi FAT1. human.
NextBioi 35493833.

Gene expression databases

Bgeei D6RCE4.
ExpressionAtlasi D6RCE4. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.60. 3 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
[Graphical view ]
Pfami PF00028. Cadherin. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 4 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 4 hits.
PROSITEi PS50268. CADHERIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiD6RCE4_HUMAN
AccessioniPrimary (citable) accession number: D6RCE4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 26, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3