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D6RBW4

- D6RBW4_HUMAN

UniProt

D6RBW4 - D6RBW4_HUMAN

Protein
Submitted name:

Inactive caspase-12

Gene

CASP12

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: InterPro
    2. regulation of apoptotic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Inactive caspase-12Imported
    Gene namesi
    Name:CASP12Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19004. CASP12.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Expressioni

    Gene expression databases

    ArrayExpressiD6RBW4.
    BgeeiD6RBW4.

    Structurei

    3D structure databases

    ProteinModelPortaliD6RBW4.
    SMRiD6RBW4. Positions 75-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C14A family.UniRule annotation
    Contains CARD domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000234399.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProiIPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00115. CASc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6RBW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADEKPSNGV LVHMVKLLIK TFLDGIFDDL MENNVLNTDE IHLIGKCLKF    50
    VVSNAENLVD DITETAQTAG KIFREHLWNS KKQLSSDISS DGEREANMPG 100
    LNIRNKEFNY LHNRNGSELD LLGMRDLLEN LGYSVVIKEN LTAQEMETAL 150
    RQFAAHPEHQ SSDSTFLVFM SHSILNGICG TKHWDQEPDV LHDDTIFEIF 200
    NNRNCQSLKD KPKMVLGLFG SPLTVEKPVQ ILMVGSCKVT SVMMLLQRLM 250
    WKRTSLLSNL PHHVQHSFET PNILTQLPTI ERLSMTRYFY LFPGN 295
    Length:295
    Mass (Da):33,616
    Last modified:July 13, 2010 - v1
    Checksum:i34D83CB9CBAA4488
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002004 Genomic DNA. No translation available.
    KF459667 Genomic DNA. No translation available.
    KF495790 Genomic DNA. No translation available.
    KF495792 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000441710; ENSP00000423970; ENSG00000204403.
    UCSCiuc031qdt.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002004 Genomic DNA. No translation available.
    KF459667 Genomic DNA. No translation available.
    KF495790 Genomic DNA. No translation available.
    KF495792 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D6RBW4.
    SMRi D6RBW4. Positions 75-295.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000441710 ; ENSP00000423970 ; ENSG00000204403 .
    UCSCi uc031qdt.1. human.

    Organism-specific databases

    HGNCi HGNC:19004. CASP12.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000234399.

    Miscellaneous databases

    NextBioi 35493681.

    Gene expression databases

    ArrayExpressi D6RBW4.
    Bgeei D6RBW4.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProi IPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00115. CASc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiD6RBW4_HUMAN
    AccessioniPrimary (citable) accession number: D6RBW4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3