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Protein
Submitted name:

Eukaryotic translation initiation factor 4E

Gene

EIF4E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: AgBase
  • eukaryotic initiation factor 4G binding Source: AgBase
  • repressing transcription factor binding Source: AgBase
  • translation initiation factor activity Source: UniProtKB-KW

Keywordsi

Molecular functionInitiation factorUniRule annotation, RNA-bindingUniRule annotation
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4EImported
Gene namesi
Name:EIF4EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000151247.12
HGNCiHGNC:3287 EIF4E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151247

PTM / Processingi

Proteomic databases

EPDiD6RBW1
MaxQBiD6RBW1
PeptideAtlasiD6RBW1
PRIDEiD6RBW1

PTM databases

iPTMnetiD6RBW1

Expressioni

Gene expression databases

BgeeiENSG00000151247
ExpressionAtlasiD6RBW1 baseline and differential

Interactioni

GO - Molecular functioni

  • enzyme binding Source: AgBase
  • eukaryotic initiation factor 4G binding Source: AgBase
  • repressing transcription factor binding Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliD6RBW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 21Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4E family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00520000055549
HOGENOMiHOG000186751

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit

Sequencei

Sequence statusi: Complete.

D6RBW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKQNKKER KKMRAEDGEN DAIKKQAESL RESQETTPTP NPPTTEEEKT
60 70 80 90 100
ESNQEVANPE HYIKHPLQNR WALWFFKNDK SKTWQANLRL ISKFDTVEDF
110 120 130 140 150
WALYNHIQLS SNLMPGCDYS LFKDGIEPMW EDEKNKRGGR WLITLNKQQR
160 170 180 190 200
RSDLDRFWLE TLLCLIGESF DDYSDDVCGA VVNVRAKGDK IAIWTTECEN
210 220 230 240
REAVTHIGRV YKERLGLPPK IVIGYQSHAD TATKSGSTTK NRFVV
Length:245
Mass (Da):28,512
Last modified:July 13, 2010 - v1
Checksum:iEB7C7BE4B064AC6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019131 Genomic DNA No translation available.
AC093836 Genomic DNA No translation available.
RefSeqiNP_001317946.1, NM_001331017.1
UniGeneiHs.13211
Hs.249718

Genome annotation databases

EnsembliENST00000504432; ENSP00000423977; ENSG00000151247
GeneIDi1977
UCSCiuc062yix.1 human

Similar proteinsi

Entry informationi

Entry nameiD6RBW1_HUMAN
AccessioniPrimary (citable) accession number: D6RBW1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health