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Protein
Submitted name:

Eukaryotic translation initiation factor 4E

Gene

EIF4E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: AgBase
  • eukaryotic initiation factor 4G binding Source: AgBase
  • repressing transcription factor binding Source: AgBase
  • translation initiation factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factorUniRule annotation

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4EImported
Gene namesi
Name:EIF4EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:3287. EIF4E.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: AgBase
  • perinuclear region of cytoplasm Source: AgBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiD6RBW1.

PTM databases

iPTMnetiD6RBW1.

Expressioni

Gene expression databases

BgeeiENSG00000151247.
ExpressionAtlasiD6RBW1. baseline and differential.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: AgBase
  • eukaryotic initiation factor 4G binding Source: AgBase
  • repressing transcription factor binding Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliD6RBW1.
SMRiD6RBW1. Positions 61-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4E family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00520000055549.
HOGENOMiHOG000186751.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiPS00813. IF4E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6RBW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKQNKKER KKMRAEDGEN DAIKKQAESL RESQETTPTP NPPTTEEEKT
60 70 80 90 100
ESNQEVANPE HYIKHPLQNR WALWFFKNDK SKTWQANLRL ISKFDTVEDF
110 120 130 140 150
WALYNHIQLS SNLMPGCDYS LFKDGIEPMW EDEKNKRGGR WLITLNKQQR
160 170 180 190 200
RSDLDRFWLE TLLCLIGESF DDYSDDVCGA VVNVRAKGDK IAIWTTECEN
210 220 230 240
REAVTHIGRV YKERLGLPPK IVIGYQSHAD TATKSGSTTK NRFVV
Length:245
Mass (Da):28,512
Last modified:July 13, 2010 - v1
Checksum:iEB7C7BE4B064AC6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019131 Genomic DNA. No translation available.
AC093836 Genomic DNA. No translation available.
RefSeqiXP_006714189.1. XM_006714126.3.
UniGeneiHs.249718.

Genome annotation databases

EnsembliENST00000504432; ENSP00000423977; ENSG00000151247.
GeneIDi1977.
UCSCiuc062yix.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019131 Genomic DNA. No translation available.
AC093836 Genomic DNA. No translation available.
RefSeqiXP_006714189.1. XM_006714126.3.
UniGeneiHs.249718.

3D structure databases

ProteinModelPortaliD6RBW1.
SMRiD6RBW1. Positions 61-245.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiD6RBW1.

Proteomic databases

PeptideAtlasiD6RBW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504432; ENSP00000423977; ENSG00000151247.
GeneIDi1977.
UCSCiuc062yix.1. human.

Organism-specific databases

CTDi1977.
HGNCiHGNC:3287. EIF4E.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00520000055549.
HOGENOMiHOG000186751.

Miscellaneous databases

ChiTaRSiEIF4E. human.
GenomeRNAii1977.

Gene expression databases

BgeeiENSG00000151247.
ExpressionAtlasiD6RBW1. baseline and differential.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiPS00813. IF4E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6RBW1_HUMAN
AccessioniPrimary (citable) accession number: D6RBW1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.