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Protein
Submitted name:

Eukaryotic translation initiation factor 4E

Gene

EIF4E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: AgBase
  • eukaryotic initiation factor 4G binding Source: AgBase
  • repressing transcription factor binding Source: AgBase
  • translation initiation factor activity Source: UniProtKB-KW

Keywordsi

Molecular functionInitiation factorUniRule annotation, RNA-bindingUniRule annotation
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4EImported
Gene namesi
Name:EIF4EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000151247.12.
HGNCiHGNC:3287. EIF4E.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151247.

PTM / Processingi

Proteomic databases

MaxQBiD6RBW1.
PeptideAtlasiD6RBW1.
PRIDEiD6RBW1.

PTM databases

iPTMnetiD6RBW1.

Expressioni

Gene expression databases

BgeeiENSG00000151247.
ExpressionAtlasiD6RBW1. baseline and differential.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: AgBase
  • eukaryotic initiation factor 4G binding Source: AgBase
  • repressing transcription factor binding Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliD6RBW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4E family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00520000055549.
HOGENOMiHOG000186751.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiView protein in InterPro
IPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiView protein in Pfam
PF01652. IF4E. 1 hit.
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiView protein in PROSITE
PS00813. IF4E. 1 hit.

Sequencei

Sequence statusi: Complete.

D6RBW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKQNKKER KKMRAEDGEN DAIKKQAESL RESQETTPTP NPPTTEEEKT
60 70 80 90 100
ESNQEVANPE HYIKHPLQNR WALWFFKNDK SKTWQANLRL ISKFDTVEDF
110 120 130 140 150
WALYNHIQLS SNLMPGCDYS LFKDGIEPMW EDEKNKRGGR WLITLNKQQR
160 170 180 190 200
RSDLDRFWLE TLLCLIGESF DDYSDDVCGA VVNVRAKGDK IAIWTTECEN
210 220 230 240
REAVTHIGRV YKERLGLPPK IVIGYQSHAD TATKSGSTTK NRFVV
Length:245
Mass (Da):28,512
Last modified:July 13, 2010 - v1
Checksum:iEB7C7BE4B064AC6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019131 Genomic DNA. No translation available.
AC093836 Genomic DNA. No translation available.
RefSeqiNP_001317946.1. NM_001331017.1.
UniGeneiHs.13211.
Hs.249718.

Genome annotation databases

EnsembliENST00000504432; ENSP00000423977; ENSG00000151247.
GeneIDi1977.
UCSCiuc062yix.1. human.

Similar proteinsi

Entry informationi

Entry nameiD6RBW1_HUMAN
AccessioniPrimary (citable) accession number: D6RBW1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported