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D6RB85

- D6RB85_HUMAN

UniProt

D6RB85 - D6RB85_HUMAN

Protein
Submitted name:

Calnexin

Gene

CANX

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. aging Source: Ensembl
    2. chaperone-mediated protein folding Source: Ensembl
    3. clathrin-mediated endocytosis Source: Ensembl
    4. synaptic vesicle endocytosis Source: Ensembl

    Keywords - Molecular functioni

    ChaperoneUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CalnexinImported
    Gene namesi
    Name:CANXImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:1473. CANX.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. dendrite cytoplasm Source: Ensembl
    3. dendritic spine Source: Ensembl
    4. endoplasmic reticulum Source: HPA
    5. integral component of membrane Source: Ensembl
    6. neuronal cell body Source: Ensembl
    7. protein complex Source: Ensembl
    8. ribosome Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulumUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiD6RB85.

    Expressioni

    Gene expression databases

    ArrayExpressiD6RB85.
    BgeeiD6RB85.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliD6RB85.
    SMRiD6RB85. Positions 60-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calreticulin family.UniRule annotation

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR001580. Calret/calnex.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view]
    PANTHERiPTHR11073. PTHR11073. 1 hit.
    PfamiPF00262. Calreticulin. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    D6RB85-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGKWLLCML LVLGTAIVEA HDGHDDDVID IEDDLDDVIE EVEDSKPDTT    50
    APPSSPKVTY KAPVPTGEVY FADSFDRGTL SGWILSKAKK DDTDDEIAKY 100
    DGKWEVEEMK ESKLPGDKGL VLMSRAKHHA ISAKLNKPFL FDTK 144
    Length:144
    Mass (Da):16,008
    Last modified:July 13, 2010 - v1
    Checksum:i70FA99DCF346993B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei144 – 1441Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113426 Genomic DNA. No translation available.
    AC136604 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000514383; ENSP00000424341; ENSG00000127022.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113426 Genomic DNA. No translation available.
    AC136604 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D6RB85.
    SMRi D6RB85. Positions 60-144.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi D6RB85.

    Proteomic databases

    PRIDEi D6RB85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000514383 ; ENSP00000424341 ; ENSG00000127022 .

    Organism-specific databases

    HGNCi HGNC:1473. CANX.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi CANX. human.
    NextBioi 35493491.

    Gene expression databases

    ArrayExpressi D6RB85.
    Bgeei D6RB85.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR001580. Calret/calnex.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view ]
    PANTHERi PTHR11073. PTHR11073. 1 hit.
    Pfami PF00262. Calreticulin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiD6RB85_HUMAN
    AccessioniPrimary (citable) accession number: D6RB85
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3