ID   D6RB29_HUMAN            Unreviewed;       133 AA.
AC   D6RB29;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Alpha kinase 1 {ECO:0000313|Ensembl:ENSP00000424492.1};
GN   Name=ALPK1 {ECO:0000313|Ensembl:ENSP00000424492.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424492.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000424492.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000424492.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC004049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC109347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6RB29; -.
DR   SMR; D6RB29; -.
DR   MassIVE; D6RB29; -.
DR   PeptideAtlas; D6RB29; -.
DR   ProteomicsDB; 13509; -.
DR   Ensembl; ENST00000509722.5; ENSP00000424492.1; ENSG00000073331.18.
DR   UCSC; uc062zbf.1; human.
DR   HGNC; HGNC:20917; ALPK1.
DR   VEuPathDB; HostDB:ENSG00000073331; -.
DR   GeneTree; ENSGT00940000159753; -.
DR   HOGENOM; CLU_2183048_0_0_1; -.
DR   ChiTaRS; ALPK1; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000073331; Expressed in buccal mucosa cell and 174 other cell types or tissues.
DR   ExpressionAtlas; D6RB29; baseline and differential.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR043529; ALPK1.
DR   PANTHER; PTHR46747; ALPHA-PROTEIN KINASE 1; 1.
DR   PANTHER; PTHR46747:SF1; ALPHA-PROTEIN KINASE 1; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:D6RB29,
KW   ECO:0007829|ProteomicsDB:D6RB29};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          77..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   133 AA;  14682 MW;  B83861858A84F51E CRC64;
     MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR GVPEGLHPRS GLCGCGGYCV
     LGGPVPVWAR RLWKTSAGRQ RSPQVAASHA NCPAGGYSPS PNLRELRKTF KSRVYSEQSN
     KQQWSNGYLA VQK
//