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Protein
Submitted name:

Protocadherin-1

Gene

PCDH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin-1Imported
Gene namesi
Name:PCDH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:8655. PCDH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156453.

PTM / Processingi

Proteomic databases

MaxQBiD6RAX3.
PaxDbiD6RAX3.
PeptideAtlasiD6RAX3.
PRIDEiD6RAX3.

Expressioni

Gene expression databases

BgeeiENSG00000156453.
ExpressionAtlasiD6RAX3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287008.

Structurei

3D structure databases

ProteinModelPortaliD6RAX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 168CadherinInterPro annotationAdd BLAST113
Domaini169 – 280CadherinInterPro annotationAdd BLAST112

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410II7Q. Eukaryota.
ENOG410XPHP. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000186073.

Family and domain databases

Gene3Di2.60.40.60. 3 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 1 hit.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6RAX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSGAGGRRC PEAALLILGP PRMEHLRHSP GPGGQRLLLP SMLLALLLLL
60 70 80 90 100
APSPGHATRV VYKVPEEQPP NTLIGSLAAD YGFPDVGHLY KLEVGAPYLR
110 120 130 140 150
VDGKTGDIFT TETSIDREGL RECQNQLPGD PCILEFEVSI TDLVQNGSPR
160 170 180 190 200
LLEGQIEVQD INDNTPNFAS PVITLAIPEN TNIGSLFPIP LASDRDAGPN
210 220 230 240 250
GVASYELQAG PEAQELFGLQ VAEDQEEKQP QLIVMGNLDR ERWDSYDLTI
260 270 280 290 300
KVQDGGSPPR ASSALLRVTV LDTNDNAPKF ERPSYEAELS ENSPIGHSVI
310 320 330 340 350
QLPHRRVTFS ATSQAQELQD PSQHSYYDSG LEESETPSSK SSSGPRLGPL
360 370 380
ALPEDHYERT TPDGSIGEME HPENEPAGRS RP
Length:382
Mass (Da):41,443
Last modified:July 13, 2010 - v1
Checksum:i189564EA26108364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094107 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000503492; ENSP00000424667; ENSG00000156453.
UCSCiuc063icv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC094107 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD6RAX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000287008.

Proteomic databases

MaxQBiD6RAX3.
PaxDbiD6RAX3.
PeptideAtlasiD6RAX3.
PRIDEiD6RAX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503492; ENSP00000424667; ENSG00000156453.
UCSCiuc063icv.1. human.

Organism-specific databases

HGNCiHGNC:8655. PCDH1.
OpenTargetsiENSG00000156453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II7Q. Eukaryota.
ENOG410XPHP. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000186073.

Miscellaneous databases

ChiTaRSiPCDH1. human.

Gene expression databases

BgeeiENSG00000156453.
ExpressionAtlasiD6RAX3. baseline and differential.

Family and domain databases

Gene3Di2.60.40.60. 3 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 1 hit.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6RAX3_HUMAN
AccessioniPrimary (citable) accession number: D6RAX3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.