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Protein
Submitted name:

Hepatocyte growth factor activator

Gene

HGFAC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei454Charge relay systemUniRule annotation1
Active sitei504Charge relay systemUniRule annotation1
Active sitei605Charge relay systemUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hepatocyte growth factor activatorImported
Gene namesi
Name:HGFACImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109758.8
HGNCiHGNC:4894 HGFAC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109758

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_500308734936 – 662Sequence analysisAdd BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi169 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 197PROSITE-ProRule annotation
Disulfide bondi250 ↔ 267PROSITE-ProRule annotation
Disulfide bondi269 ↔ 278PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiD6RAR4
PRIDEiD6RAR4

Expressioni

Gene expression databases

BgeeiENSG00000109758
ExpressionAtlasiD6RAR4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliD6RAR4
SMRiD6RAR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 150Fibronectin type-IIInterPro annotationAdd BLAST48
Domaini160 – 198EGF-likeInterPro annotationAdd BLAST39
Domaini200 – 240Fibronectin type-IInterPro annotationAdd BLAST41
Domaini241 – 279EGF-likeInterPro annotationAdd BLAST39
Domaini285 – 367KringleInterPro annotationAdd BLAST83
Domaini415 – 653Peptidase S1InterPro annotationAdd BLAST239

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, KringlePROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
KOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119133
HOGENOMiHOG000237314
OMAiYQELHVD
OrthoDBiEOG091G0AH5
PhylomeDBiD6RAR4

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00190 Tryp_SPc, 1 hit
Gene3Di2.10.10.10, 1 hit
2.40.20.10, 1 hit
InterProiView protein in InterPro
IPR014394 Coagulation_fac_XII/HGFA
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000083 Fibronectin_type1
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00039 fn1, 1 hit
PF00040 fn2, 1 hit
PF00051 Kringle, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001146 Factor_XII_HGFA, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00058 FN1, 1 hit
SM00059 FN2, 1 hit
SM00130 KR, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01253 FN1_1, 1 hit
PS51091 FN1_2, 1 hit
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

D6RAR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT
60 70 80 90 100
ATPAIPTILV TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA
110 120 130 140 150
LTEDGRPCRF PFRYGGRMLH ACTSEGSAHR KWCATTHNYD RDRAWGYCVE
160 170 180 190 200
ATPPPGGPAA LDPCASGPCL NGGSCSNTQD PQSYHCSCPR AFTGKDCGTE
210 220 230 240 250
KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT RHTACLSSPC
260 270 280 290 300
LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST
310 320 330 340 350
SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY
360 370 380 390 400
VVKDSALSWE YCRLEACDLE TEGRESLTRV QLSPDLLATL PEPASPGRQA
410 420 430 440 450
CGRRHKKRTF LRPRIIGGSS SLPGSHPWLA AIYIGDSFCA GSLVHTCWVV
460 470 480 490 500
SAAHCFSHSP PRDSVSVVLG QHFFNRTTDV TQTFGIEKYI PYTLYSVFNP
510 520 530 540 550
SDHDLVLIRL KKKGDRCATR SQFVQPICLP EPGSTFPAGH KCQIAGWGHL
560 570 580 590 600
DENVSGYSSS LREALVPLVA DHKCSSPEVY GADISPNMLC AGYFDCKSDA
610 620 630 640 650
CQGDSGGPLA CEKNGVAYLY GIISWGDGCG RLHKPGVYTR VANYVDWIND
660
RIRPPRRLVA PS
Length:662
Mass (Da):71,483
Last modified:July 13, 2010 - v1
Checksum:iF2A3D607370547F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590235 Genomic DNA No translation available.
RefSeqiNP_001284368.1, NM_001297439.1
UniGeneiHs.104

Genome annotation databases

EnsembliENST00000511533; ENSP00000421801; ENSG00000109758
GeneIDi3083
UCSCiuc010icw.4 human

Similar proteinsi

Entry informationi

Entry nameiD6RAR4_HUMAN
AccessioniPrimary (citable) accession number: D6RAR4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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