ID   D6RAE3_HUMAN            Unreviewed;       354 AA.
AC   D6RAE3;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Spectrin repeat containing nuclear envelope family member 4 {ECO:0000313|Ensembl:ENSP00000422716.1};
DE   Flags: Fragment;
GN   Name=SYNE4 {ECO:0000313|Ensembl:ENSP00000422716.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422716.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422716.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000422716.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC002116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF038458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6RAE3; -.
DR   SMR; D6RAE3; -.
DR   MassIVE; D6RAE3; -.
DR   PeptideAtlas; D6RAE3; -.
DR   ProteomicsDB; 13301; -.
DR   Antibodypedia; 34811; 135 antibodies from 18 providers.
DR   Ensembl; ENST00000490730.1; ENSP00000422716.1; ENSG00000181392.17.
DR   UCSC; uc060xlh.1; human.
DR   HGNC; HGNC:26703; SYNE4.
DR   VEuPathDB; HostDB:ENSG00000181392; -.
DR   GeneTree; ENSGT00510000049061; -.
DR   HOGENOM; CLU_034166_0_0_1; -.
DR   ChiTaRS; SYNE4; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000181392; Expressed in pancreatic ductal cell and 117 other cell types or tissues.
DR   ExpressionAtlas; D6RAE3; baseline and differential.
DR   GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:InterPro.
DR   InterPro; IPR030268; SYNE4.
DR   PANTHER; PTHR21640:SF1; NESPRIN-4; 1.
DR   PANTHER; PTHR21640; UNCHARACTERIZED; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:D6RAE3,
KW   ECO:0007829|MaxQB:D6RAE3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          219..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         354
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000422716.1"
SQ   SEQUENCE   354 AA;  37601 MW;  F43E886F6584642C CRC64;
     MALSLPLGPR LGSEPLNHPP GAPREADIVG CTVCPASGEE STSPEQAQTL GQDSLGPPEH
     FQGGPRGNEP AAHPPRWSTP SSYEDPAGGK HCEHPISGLE VLEAEQNSLH LCLLGLGRRL
     QDLEQGLGHW ALAQSGMVQL QALQVDLRGA AERVEALLAF GEGLAQRSEP RAWAALEQIL
     RALGAYRDSI FRRLWQLQAQ LVSYSLVFEE ANTLDQDLEV EGDSDWPGPG SRHLSLPTGH
     AGVWPRPPET LSTSPKTLPA PEASGQEEAS ISSSPGCEAG GESRGPRSCI QAASDLPPYP
     LPPLPPPGGC HVSPARVRRP LLLSCPNTQD TLPGAQLCQW SSPSLMCVIN GHCQ
//