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Protein
Submitted name:

Probable ATP-dependent RNA helicase YTHDC2

Gene

YTHDC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Probable ATP-dependent RNA helicase YTHDC2Imported
Gene namesi
Name:YTHDC2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000047188.15.
HGNCiHGNC:24721. YTHDC2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047188.

PTM / Processingi

Proteomic databases

MaxQBiD6RA70.
PaxDbiD6RA70.
PeptideAtlasiD6RA70.
PRIDEiD6RA70.

Expressioni

Gene expression databases

BgeeiENSG00000047188.
ExpressionAtlasiD6RA70. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliD6RA70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 106R3HInterPro annotationAdd BLAST69
Domaini203 – 369Helicase ATP-bindingInterPro annotationAdd BLAST167
Domaini487 – 571ANK_REP_REGIONInterPro annotationAdd BLAST85
Repeati506 – 538ANKPROSITE-ProRule annotationAdd BLAST33
Domaini612 – 739Helicase C-terminalInterPro annotationAdd BLAST128

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0920. Eukaryota.
KOG0922. Eukaryota.
KOG1902. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00760000119189.
HOGENOMiHOG000205632.

Family and domain databases

CDDicd00204. ANK. 1 hit.
cd06007. R3H_DEXH_helicase. 1 hit.
Gene3Di1.25.40.20. 1 hit.
3.30.1370.50. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR034083. R3H_DEXH_helicase.
IPR001374. R3H_dom.
IPR036867. R3H_dom_sf.
IPR031083. YTHDC2-related.
PANTHERiPTHR18934:SF125. PTHR18934:SF125. 1 hit.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF01424. R3H. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00393. R3H. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF82708. SSF82708. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51061. R3H. 1 hit.

Sequencei

Sequence statusi: Complete.

D6RA70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPSSVSPR QPAPGGGGGG GPSPCGPGGG GRAKGLKDIR IDEEVKIAVN
60 70 80 90 100
IALERFRYGD QREMEFPSSL TSTERAFIHR LSQSLGLVSK SKGKGANRYL
110 120 130 140 150
TVKKKDGSET AHAMMTCNLT HNTKHAVRSL IQRFPVTNKE RTELLPKTER
160 170 180 190 200
GNVFAVEAEN REMSKTSGRL NNGIPQIPVK RGESEFDSFR QSLPVFEKQE
210 220 230 240 250
EIVKIIKENK VVLIVGETGS GKTTQIPQFL LDDCFKNGIP CRIFCTQPRR
260 270 280 290 300
LAAIAVAERV AAERRERIGQ TIGYQIRLES RVSPKTLLTF CTNGVLLRTL
310 320 330 340 350
MAGDSTLSTV THVIVDEVHE RDRFSDFLLT KLRDLLQKHP TLKLILSSAA
360 370 380 390 400
LDVNLFIRYF GSCPVIYIQG RPFEVKEMFL EDILRTTGYT NKEMLKYKKE
410 420 430 440 450
KQQEEKQQTT LTEWYSAQEN SFKPESQRQR TVLNVTDEYD LLDDGGDAVF
460 470 480 490 500
SQLTEKDVNC LEPWLIKEMD ACLSDIWLHK DIDAFAQVFH LILTENVSVD
510 520 530 540 550
YRHSETSATA LMVAAGRGFA SQVEQLISMG ANVHSKASNG WMALDWAKHF
560 570 580 590 600
GQTEIVDLLE SYSATLEFGN LDESSLVQTN GSDLSAEDRE LLKAYHHSFD
610 620 630 640 650
DEKVDLDLIM HLLYNICHSC DAGAVLIFLP GYDEIVGLRD RILFDDKRFA
660 670 680 690 700
DSTHRYQVFM LHSNMQTSDQ KKVLKNPPAG VRKIILSTNI AETSITVNDV
710 720 730
VFVIDSGKVK EKSFDALNFV TMLKMVWISK ASAIQRKGR
Length:739
Mass (Da):82,989
Last modified:July 13, 2010 - v1
Checksum:i8599A5AB1BB61128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010389 Genomic DNA. No translation available.
AC093208 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000515883; ENSP00000423101; ENSG00000047188.
UCSCiuc010jce.3. human.

Similar proteinsi

Entry informationi

Entry nameiD6RA70_HUMAN
AccessioniPrimary (citable) accession number: D6RA70
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 25, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported