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Protein
Submitted name:

Alpha-synuclein

Gene

SNCA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. arachidonic acid binding Source: Ensembl
  2. phospholipid binding Source: Ensembl

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. aging Source: Ensembl
  3. behavioral response to cocaine Source: Ensembl
  4. cellular response to fibroblast growth factor stimulus Source: Ensembl
  5. cellular response to oxidative stress Source: Ensembl
  6. dopamine biosynthetic process Source: Ensembl
  7. fatty acid metabolic process Source: Ensembl
  8. long-term synaptic potentiation Source: Ensembl
  9. microglial cell activation Source: Ensembl
  10. mitochondrial ATP synthesis coupled electron transport Source: Ensembl
  11. mitochondrial membrane organization Source: Ensembl
  12. negative regulation of dopamine metabolic process Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. negative regulation of protein phosphorylation Source: Ensembl
  15. neutral lipid metabolic process Source: Ensembl
  16. phospholipid metabolic process Source: Ensembl
  17. positive regulation of neurotransmitter secretion Source: Ensembl
  18. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  19. regulation of acyl-CoA biosynthetic process Source: Ensembl
  20. regulation of dopamine secretion Source: Ensembl
  21. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  22. regulation of glutamate secretion Source: Ensembl
  23. regulation of locomotion Source: Ensembl
  24. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  25. regulation of macrophage activation Source: Ensembl
  26. response to drug Source: Ensembl
  27. synapse organization Source: Ensembl
  28. synaptic transmission, dopaminergic Source: Ensembl
  29. synaptic vesicle endocytosis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-synucleinImported
Gene namesi
Name:SNCAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:11138. SNCA.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: Ensembl
  2. cytoskeleton Source: Ensembl
  3. cytosol Source: Ensembl
  4. Golgi apparatus Source: Ensembl
  5. growth cone Source: Ensembl
  6. inclusion body Source: Ensembl
  7. mitochondrion Source: Ensembl
  8. nuclear outer membrane Source: Ensembl
  9. plasma membrane Source: Ensembl
  10. ribosome Source: Ensembl
  11. rough endoplasmic reticulum Source: Ensembl
  12. synaptic vesicle Source: Ensembl
  13. terminal bouton Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD6RA31.
ExpressionAtlasiD6RA31. baseline and differential.

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the synuclein family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016161.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Fragment.

D6RA31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60
GVATVAEKTK EQVTNV
Length:66
Mass (Da):6,820
Last modified:February 4, 2015 - v4
Checksum:iA5AF3A5CF47EEE3E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei66 – 661Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093759 Genomic DNA. No translation available.
AC097478 Genomic DNA. No translation available.
AC108208 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000506691; ENSP00000423445; ENSG00000145335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093759 Genomic DNA. No translation available.
AC097478 Genomic DNA. No translation available.
AC108208 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiD6RA31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506691; ENSP00000423445; ENSG00000145335.

Organism-specific databases

HGNCiHGNC:11138. SNCA.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000016161.

Miscellaneous databases

ChiTaRSiSNCA. human.
NextBioi35493137.

Gene expression databases

BgeeiD6RA31.
ExpressionAtlasiD6RA31. baseline and differential.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiD6RA31_HUMAN
AccessioniPrimary (citable) accession number: D6RA31
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: February 4, 2015
Last modified: February 4, 2015
This is version 31 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.