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Protein
Submitted name:

Alpha-synuclein

Gene

SNCA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-synucleinImported
Gene namesi
Name:SNCAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:11138. SNCA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiD6RA31.
PeptideAtlasiD6RA31.

Expressioni

Gene expression databases

BgeeiENSG00000145335.
ExpressionAtlasiD6RA31. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000338345.

Family & Domainsi

Sequence similaritiesi

Belongs to the synuclein family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IWI2. Eukaryota.
ENOG4111TDZ. LUCA.
GeneTreeiENSGT00390000016161.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PTHR13820:SF5. PTHR13820:SF5. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Fragment.

D6RA31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60
GVATVAEKTK EQVTNVG
Length:67
Mass (Da):6,877
Last modified:February 17, 2016 - v7
Checksum:i4D95AF3A5CF47EEE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei67 – 671Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093759 Genomic DNA. No translation available.
AC097478 Genomic DNA. No translation available.
AC108208 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000506691; ENSP00000423445; ENSG00000145335.
UCSCiuc062yfe.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093759 Genomic DNA. No translation available.
AC097478 Genomic DNA. No translation available.
AC108208 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000338345.

Proteomic databases

PaxDbiD6RA31.
PeptideAtlasiD6RA31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000506691; ENSP00000423445; ENSG00000145335.
UCSCiuc062yfe.1. human.

Organism-specific databases

HGNCiHGNC:11138. SNCA.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWI2. Eukaryota.
ENOG4111TDZ. LUCA.
GeneTreeiENSGT00390000016161.

Miscellaneous databases

ChiTaRSiSNCA. human.

Gene expression databases

BgeeiENSG00000145335.
ExpressionAtlasiD6RA31. baseline and differential.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PTHR13820:SF5. PTHR13820:SF5. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01211. SYNUCLEIN.
ProtoNetiSearch...

Entry informationi

Entry nameiD6RA31_HUMAN
AccessioniPrimary (citable) accession number: D6RA31
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: February 17, 2016
Last modified: September 7, 2016
This is version 43 of the entry and version 7 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.