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D6RA31

- D6RA31_HUMAN

UniProt

D6RA31 - D6RA31_HUMAN

Protein
Submitted name:

Alpha-synuclein

Gene

SNCA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. arachidonic acid binding Source: Ensembl
    2. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. aging Source: Ensembl
    3. behavioral response to cocaine Source: Ensembl
    4. cellular response to fibroblast growth factor stimulus Source: Ensembl
    5. cellular response to oxidative stress Source: Ensembl
    6. dopamine biosynthetic process Source: Ensembl
    7. fatty acid metabolic process Source: Ensembl
    8. long-term synaptic potentiation Source: Ensembl
    9. microglial cell activation Source: Ensembl
    10. mitochondrial ATP synthesis coupled electron transport Source: Ensembl
    11. mitochondrial membrane organization Source: Ensembl
    12. negative regulation of dopamine metabolic process Source: Ensembl
    13. negative regulation of neuron apoptotic process Source: Ensembl
    14. negative regulation of protein phosphorylation Source: Ensembl
    15. neutral lipid metabolic process Source: Ensembl
    16. phospholipid metabolic process Source: Ensembl
    17. positive regulation of neurotransmitter secretion Source: Ensembl
    18. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    19. regulation of acyl-CoA biosynthetic process Source: Ensembl
    20. regulation of dopamine secretion Source: Ensembl
    21. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    22. regulation of glutamate secretion Source: Ensembl
    23. regulation of locomotion Source: Ensembl
    24. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    25. regulation of macrophage activation Source: Ensembl
    26. response to drug Source: Ensembl
    27. synapse organization Source: Ensembl
    28. synaptic transmission, dopaminergic Source: Ensembl
    29. synaptic vesicle endocytosis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha-synucleinImported
    Gene namesi
    Name:SNCAImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:11138. SNCA.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: Ensembl
    2. cytoskeleton Source: Ensembl
    3. cytosol Source: Ensembl
    4. Golgi apparatus Source: Ensembl
    5. growth cone Source: Ensembl
    6. mitochondrion Source: Ensembl
    7. nuclear outer membrane Source: Ensembl
    8. plasma membrane Source: Ensembl
    9. ribosome Source: Ensembl
    10. rough endoplasmic reticulum Source: Ensembl
    11. synaptic vesicle Source: Ensembl
    12. terminal bouton Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiD6RA31.
    BgeeiD6RA31.

    Structurei

    3D structure databases

    ProteinModelPortaliD6RA31.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.287.700. 1 hit.
    InterProiIPR001058. Synuclein.
    [Graphical view]
    PANTHERiPTHR13820. PTHR13820. 1 hit.
    PfamiPF01387. Synuclein. 1 hit.
    [Graphical view]
    PRINTSiPR01211. SYNUCLEIN.

    Sequencei

    Sequence statusi: Fragment.

    D6RA31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH   50
    GVATVAEKTK EQVTNV 66
    Length:66
    Mass (Da):6,820
    Last modified:May 14, 2014 - v2
    Checksum:iA5AF3A5CF47EEE3E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei66 – 661Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093759 Genomic DNA. No translation available.
    AC097478 Genomic DNA. No translation available.
    AC108208 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000506691; ENSP00000423445; ENSG00000145335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093759 Genomic DNA. No translation available.
    AC097478 Genomic DNA. No translation available.
    AC108208 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali D6RA31.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000506691 ; ENSP00000423445 ; ENSG00000145335 .

    Organism-specific databases

    HGNCi HGNC:11138. SNCA.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi SNCA. human.
    NextBioi 35493137.

    Gene expression databases

    ArrayExpressi D6RA31.
    Bgeei D6RA31.

    Family and domain databases

    Gene3Di 1.10.287.700. 1 hit.
    InterProi IPR001058. Synuclein.
    [Graphical view ]
    PANTHERi PTHR13820. PTHR13820. 1 hit.
    Pfami PF01387. Synuclein. 1 hit.
    [Graphical view ]
    PRINTSi PR01211. SYNUCLEIN.
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiD6RA31_HUMAN
    AccessioniPrimary (citable) accession number: D6RA31
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 27 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3