ID   D6R9U8_HUMAN            Unreviewed;       116 AA.
AC   D6R9U8;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=3-hydroxybutyrate dehydrogenase 2 {ECO:0000313|Ensembl:ENSP00000422891.1};
DE   Flags: Fragment;
GN   Name=BDH2 {ECO:0000313|Ensembl:ENSP00000422891.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422891.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000422891.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000422891.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
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DR   EMBL; AC097485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6R9U8; -.
DR   SMR; D6R9U8; -.
DR   MassIVE; D6R9U8; -.
DR   MaxQB; D6R9U8; -.
DR   PeptideAtlas; D6R9U8; -.
DR   ProteomicsDB; 13125; -.
DR   Antibodypedia; 26090; 223 antibodies from 28 providers.
DR   Ensembl; ENST00000509245.1; ENSP00000422891.1; ENSG00000164039.15.
DR   UCSC; uc062yqw.1; human.
DR   HGNC; HGNC:32389; BDH2.
DR   VEuPathDB; HostDB:ENSG00000164039; -.
DR   GeneTree; ENSGT00940000156721; -.
DR   OMA; SMDGGWT; -.
DR   ChiTaRS; BDH2; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000164039; Expressed in mucosa of stomach and 124 other cell types or tissues.
DR   ExpressionAtlas; D6R9U8; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0008667; F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0019290; P:siderophore biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR003560; DHB_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43477:SF4; 3-HYDROXYBUTYRATE DEHYDROGENASE TYPE 2; 1.
DR   PANTHER; PTHR43477; DIHYDROANTICAPSIN 7-DEHYDROGENASE; 1.
DR   Pfam; PF13561; adh_short_C2; 1.
DR   PRINTS; PR01397; DHBDHDRGNASE.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   1: Evidence at protein level;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Proteomics identification {ECO:0007829|EPD:D6R9U8,
KW   ECO:0007829|MaxQB:D6R9U8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   NON_TER         116
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000422891.1"
SQ   SEQUENCE   116 AA;  12929 MW;  B7E86E8023CBBAB6 CRC64;
     MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT
     KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAF
//