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Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 18

Gene

USP17L18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89NucleophilePROSITE-ProRule annotation1
Active sitei334Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 18 (EC:3.4.19.12)
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000250844.2.
HGNCiHGNC:44446. USP17L18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiUSP17L18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004210921 – 530Ubiquitin carboxyl-terminal hydrolase 17-like protein 18Add BLAST530

Proteomic databases

PaxDbiD6R9N7.
PRIDEiD6R9N7.

Expressioni

Gene expression databases

BgeeiENSG00000250844.
ExpressionAtlasiD6R9N7. baseline.

Organism-specific databases

HPAiHPA045642.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000423503.

Structurei

3D structure databases

ProteinModelPortaliD6R9N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 375USPAdd BLAST296

Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1865. Eukaryota.
ENOG410XQ92. LUCA.
GeneTreeiENSGT00890000139343.
HOGENOMiHOG000144638.
InParanoidiD6R9N7.
PhylomeDBiD6R9N7.
TreeFamiTF315281.

Family and domain databases

InterProiView protein in InterPro
IPR006861. HABP4_PAIRBP1-bd.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
PfamiView protein in Pfam
PF04774. HABP4_PAI-RBP1. 1 hit.
PF00443. UCH. 1 hit.
PROSITEiView protein in PROSITE
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

D6R9N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY
110 120 130 140 150
TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA
160 170 180 190 200
AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY
210 220 230 240 250
WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN
260 270 280 290 300
AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC
310 320 330 340 350
LDMQPYMSQT NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RRAKQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF
460 470 480 490 500
NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS STTPTHQESM
510 520 530
NTGTLASLRG RARRSKGKNK HSKRALLVCQ
Length:530
Mass (Da):59,657
Last modified:July 13, 2010 - v1
Checksum:iFA9EF6C19DA00537
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108519 Genomic DNA. No translation available.
CCDSiCCDS59459.1.
RefSeqiNP_001243788.1. NM_001256859.1.
UniGeneiHs.741138.

Genome annotation databases

EnsembliENST00000504209; ENSP00000423503; ENSG00000250844.
GeneIDi100287364.
KEGGihsa:100287364.
UCSCiuc011bwp.2. human.

Similar proteinsi

Entry informationi

Entry nameiU17LI_HUMAN
AccessioniPrimary (citable) accession number: D6R9N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: July 13, 2010
Last modified: September 27, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes it impossible to specifically assign data to a particular gene of the family. Oligonucleotides designed in RNAi experiments are for instance not specific for a given UPS17-like gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families