ID   D6R9A1_HUMAN            Unreviewed;        84 AA.
AC   D6R9A1;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=RAD1 checkpoint DNA exonuclease {ECO:0000313|Ensembl:ENSP00000421007.1};
GN   Name=RAD1 {ECO:0000313|Ensembl:ENSP00000421007.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421007.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000421007.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0007829|PubMed:22814378}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [3] {ECO:0000313|Ensembl:ENSP00000421007.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the rad1 family.
CC       {ECO:0000256|ARBA:ARBA00010991}.
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DR   EMBL; AC026801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6R9A1; -.
DR   SMR; D6R9A1; -.
DR   MassIVE; D6R9A1; -.
DR   MaxQB; D6R9A1; -.
DR   PeptideAtlas; D6R9A1; -.
DR   ProteomicsDB; 12946; -.
DR   Antibodypedia; 10031; 371 antibodies from 33 providers.
DR   Ensembl; ENST00000513914.5; ENSP00000421007.1; ENSG00000113456.20.
DR   UCSC; uc063cwx.1; human.
DR   HGNC; HGNC:9806; RAD1.
DR   VEuPathDB; HostDB:ENSG00000113456; -.
DR   GeneTree; ENSGT00500000044913; -.
DR   HOGENOM; CLU_193132_0_0_1; -.
DR   ChiTaRS; RAD1; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113456; Expressed in secondary oocyte and 223 other cell types or tissues.
DR   ExpressionAtlas; D6R9A1; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:InterPro.
DR   Gene3D; 3.70.10.10; -; 1.
DR   InterPro; IPR003021; Rad1_Rec1_Rad17.
DR   PANTHER; PTHR10870; CELL CYCLE CHECKPOINT PROTEIN RAD1; 1.
DR   PANTHER; PTHR10870:SF0; CELL CYCLE CHECKPOINT PROTEIN RAD1; 1.
DR   Pfam; PF02144; Rad1; 1.
DR   PRINTS; PR01245; RAD1REC1.
PE   1: Evidence at protein level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
SQ   SEQUENCE   84 AA;  9162 MW;  FDF7BE1C83D733C3 CRC64;
     MPLLTQQIQD EDDQYSLVAS LDNVRNLSTI LKAIHFREHA TCFATKNGIK VTVENAKCVQ
     ANAFIQGHGM VAHTCISSCS GDRG
//