D6HUV9 (D6HUV9_ECOLX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase HAMAP-Rule MF_00210 RuleBase RU000531
EC=2.5.1.19 HAMAP-Rule MF_00210 RuleBase RU000531

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase HAMAP-Rule MF_00210

Gene names

Name:	aroA HAMAP-Rule MF_00210
ORF Names:	ECCG_01330 EMBL EFE63446.2

Organism

Escherichia coli B088 EMBL EFE63446.2

Taxonomic identifier

550672 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP-Rule MF_00210 RuleBase RU000531 SAAS SAAS023193
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP-Rule MF_00210 SAAS SAAS023193
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00210 SAAS SAAS023193
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00210.
Sequence similarities	Belongs to the EPSP synthase family. RuleBase RU004164 HAMAP-Rule MF_00210

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP-Rule MF_00210 RuleBase RU000531 SAAS SAAS023193
Cellular component	Cytoplasm HAMAP-Rule MF_00210 SAAS SAAS023193
Molecular function	Transferase HAMAP-Rule MF_00210 RuleBase RU000531 SAAS SAAS023193 EMBL EFE63446.2
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D6HUV9 [UniParc]. Last modified July 13, 2010. Version 1. Checksum: B1F55469EB4D9F97	FASTA	427	46,096
	10 20 30 40 50 60 MESLTLQPIA RVDGTINLPG SKSVSNRALL LAALAHGKTV LTNLLDSDDV RHMLNALTAL 70 80 90 100 110 120 GVSYTLSADR TRCEIIGNGG PLHAEGALEL FLGNAGTAMR PLAAALCLGS NDIVLTGEPR 130 140 150 160 170 180 MKERPIGHLV DALRLGGAKI TYLEQENYPP LRLQGGFTGG NVDVDGSVSS QFLTALLMTA 190 200 210 220 230 240 PLAPEDTVIR IKGDLVSKPY IDITLNLMKT FGVEIENQHY QQFVVKGGQS YQSPGTYLVE 250 260 270 280 290 300 GDASSASYFL AAAAIKGGTV KVTGIGRNSM QGDIRFADVL EKMGATICWG DDYISCTRGE 310 320 330 340 350 360 LNAIDMDMNH IPDAAMTIAT AALFAKGTTT LRNIYNWRVK ETDRLFAMAT ELRKVGAEVE 370 380 390 400 410 420 EGHDYIRITP PEKLNFAEIA TYNDHRMAMC FSLVALSDTP VTILDPKCTA KTFPDYFEQL ARISQAA

References

[1]

"The Genome Sequence of Escherichia coli B088." The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S. , Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B. Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: B088 EMBL EFE63446.2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG749133 Genomic DNA. Translation: EFE63446.2.
3D structure databases
ProteinModelPortal	D6HUV9.
SMR	D6HUV9. Positions 1-427.
ModBase	Search...
Proteomic databases
PRIDE	D6HUV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EFE63446; EFE63446; ECCG_01330.
PATRIC	35854976. VBIEscCol142334_1185.
Phylogenomic databases
OMA	GADIEWG.
Enzyme and pathway databases
UniPathway	UPA00053; UER00089.
Family and domain databases
Gene3D	3.65.10.10. 2 hits.
HAMAP	MF_00210. EPSP_synth.
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	D6HUV9.

Entry information

Entry name

D6HUV9_ECOLX

Accession

Primary (citable) accession number: D6HUV9

Entry history

Integrated into UniProtKB/TrEMBL:	July 13, 2010
Last sequence update:	July 13, 2010
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)