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D6GSH4 (D6GSH4_FILAD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:HMPREF0389_00532 EMBL EFE28615.1
OrganismFilifactor alocis (strain ATCC 35896 / D40 B5) (Fusobacterium alocis) [Complete proteome] [HAMAP] EMBL EFE28615.1
Taxonomic identifier546269 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeFilifactor

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain140 – 343204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding169 – 22456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2961Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3101Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3101Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3121Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D6GSH4 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: C802EB7D96CA3688

FASTA35340,303
        10         20         30         40         50         60 
MVKQNIAILF GGKSEEHEVS CRSAKYIFEN VDRDKYRPFL IGIDKLGNYY YMKECNIEHL 

        70         80         90        100        110        120 
IDCTWTDFIE TNEVCFSKGD ERFTLQLQGE KIVFDVVFPA LHGPNGEDGK LQGLMEFVNI 

       130        140        150        160        170        180 
PYVGCNSISS AICMDKEITK RLVGIEGVRQ VPYVILYEGV VAEEKLLEME EIGYPLFVKP 

       190        200        210        220        230        240 
ANMGSSVGVS KAENQQELLQ AIRVASKYDD KVIVEKGIDA LELEIAALGD GKDAYFSTVG 

       250        260        270        280        290        300 
CIKPRDIFYD YDSKYLTNDA DFYIPAPISF EKETELREMA RKAYTAMLCE GLSRIDFFMD 

       310        320        330        340        350 
KETQEIYFNE INTMPGFTAI SLYPQLMDYD GVGAKELIGR LIDYAWRRYE KNK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002390 Genomic DNA. Translation: EFE28615.1.
RefSeqYP_005053848.1. NC_016630.1.

3D structure databases

ProteinModelPortalD6GSH4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEFE28615; EFE28615; HMPREF0389_00532.
GeneID11570312.
KEGGfaa:HMPREF0389_00532.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAQIDVIFP.

Enzyme and pathway databases

BioCycFALO546269:GHHW-98-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD6GSH4_FILAD
AccessionPrimary (citable) accession number: D6GSH4
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)