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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei209 – 2091UniRule annotation
Active sitei649 – 6491UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciTARS426114-WGS:GSYJ-2172-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:THI_2269Imported
OrganismiThiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)Imported
Taxonomic identifieri426114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesThiomonas
ProteomesiUP000002372: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6CUE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEFGAWKAT DRGIAVRSAC GSAIPESVRA RILLRFVWAL IASLRPNFVP
60 70 80 90 100
IQPLFAMSTR PSTARNASDP DAPLFDDIRL LGRLLGDLIR EQEGQEMFDI
110 120 130 140 150
VETVRQLSVK FHRDGDAKDR RALDKLLSSL SRDQAVSVIR AFSYFSILAN
160 170 180 190 200
IAEDHHVLRR AEQDAERGAP PQRDSVRAAL ETLKDSGVDR QQLLQFFDQA
210 220 230 240 250
LISPVLTAHP TEVQRKSVLD AERALARLLV ERDATRLPQK RADIEDAMRA
260 270 280 290 300
RVVQLWQTRL LRYVKLKVSD EIKNALSFYG ATFFSQFPRL YRNLERDIEA
310 320 330 340 350
LFPAGGQDLA KTDLPAFFRM GHWIGGDRDG NPFVTADTLS YALRMQSRTA
360 370 380 390 400
IEFYMAEVHA IGGELSISAL LASASPELMA LAEQSPDLSE HRSDEPYRRA
410 420 430 440 450
LIGMYARLAA NLRKLAGVQA LLPEVGSAEP YANADEFIAD LRIIHDSLHR
460 470 480 490 500
HHAGPLAQTR LDPLIRAAGV FGFRLATIDL RQSSDQHEAV LRELLAAAGL
510 520 530 540 550
CPDYSHLDEA AKQALLIRCL NDPRPLRLPH HVYSDWARSE LAVFDRAYSA
560 570 580 590 600
RRDFGPRAIR QYIISHSETV SDLLELLLLQ KEAGLFHGTL GSHDSYAELL
610 620 630 640 650
VAPLFETIED LRNAPAIMRD FYALPGIAGL VQRSGGEQEI MLGYSDSNKD
660 670 680 690 700
GGFFTSNWEL YCAEVALAEQ FEQLKAEHGI TLRLFHGRGG TVGRGGGPSF
710 720 730 740 750
DAILAQPPGT VNGQIRLTEQ GEVITSKYGN PEIGLRNLET LVAATLQATL
760 770 780 790 800
LPQTKTASKP PARFLDAAAA LSEASMAAYR KLVYETPEFT DYFYSATPIS
810 820 830 840 850
EIAELNIGSR PSSRKATRAI ADLRAIPWGF SWGQCRVALP GWYGFGSGVQ
860 870 880 890 900
AFLDANPDGL KLLQRMAKQW PFFATLLSNI DMVLAKTDLR VAQRYAELVA
910 920 930 940 950
DSKTRQKVLK ALLREWQLTT DMLTAITGNT ERLADNPTLK RSIRARFPYI
960 970 980 990
DPLNHLQIEL LHRFREGQTD ERTKRGIHLS INGIAAGLRN TG
Length:992
Mass (Da):110,371
Last modified:July 13, 2010 - v1
Checksum:i73375CB8A2782F1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP475956 Genomic DNA. Translation: CAZ88913.1.
RefSeqiWP_013106216.1. NC_014145.1.
YP_003624726.1. NC_014145.1.

Genome annotation databases

EnsemblBacteriaiCAZ88913; CAZ88913; THI_2269.
GeneIDi13879962.
KEGGithi:THI_2269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP475956 Genomic DNA. Translation: CAZ88913.1.
RefSeqiWP_013106216.1. NC_014145.1.
YP_003624726.1. NC_014145.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAZ88913; CAZ88913; THI_2269.
GeneIDi13879962.
KEGGithi:THI_2269.

Phylogenomic databases

HOGENOMiHOG000238647.
KOiK01595.

Enzyme and pathway databases

BioCyciTARS426114-WGS:GSYJ-2172-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Genoscope - CEA
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3As.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22701 / CIP 110005 / 3AsImported.

Entry informationi

Entry nameiD6CUE4_THIA3
AccessioniPrimary (citable) accession number: D6CUE4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 4, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.