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D6CRB3 (D6CRB3_THIA3) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlB EMBL CAZ87154.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:THI_0404 EMBL CAZ87154.1
OrganismThiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As) [Complete proteome] [HAMAP] EMBL CAZ87154.1
Taxonomic identifier426114 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesThiomonas

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain111 – 311201ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding137 – 19256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2641Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2781Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2781Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2801Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D6CRB3 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: A8415C11FACABEE0

FASTA37840,418
        10         20         30         40         50         60 
MTPWPQIDPR GLGRVAVLMG GLSAEREVSL MSGKGVLAAL QSRGVDAFAF DPSVDDLAAL 

        70         80         90        100        110        120 
KSFGAQRAFI NLHGRWGEDG TVQGALELLG IPYTGPGVLA SALAIDKAMT KRLWHFENLS 

       130        140        150        160        170        180 
TPKWREVGTL IEARAAAAEL GFPLIFKATH EGSTLGLKRA DSEAEVQAAY LEAARFDSRV 

       190        200        210        220        230        240 
LVEQFIEGDE VTCAVIGAGD QARALPLIRI VAPGGNYDYE HKYFSDDTRY ICPSELPADE 

       250        260        270        280        290        300 
EARIQDLVLR SYRTLGCRGW ARADVMIRAT DRQPFLLEIN TSPGMTSHSL VPMAARVAGL 

       310        320        330        340        350        360 
EYADLCLLIL SMAALDQPHK GVDPQAAASP ALPPEEAIPT PALPTSGEGA NTPPPRRGGG 

       370 
WEGEKPALGR PGGGRSDR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FP475956 Genomic DNA. Translation: CAZ87154.1.
RefSeqYP_003623017.1. NC_014145.1.

3D structure databases

ProteinModelPortalD6CRB3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAZ87154; CAZ87154; THI_0404.
GeneID13880247.
KEGGthi:THI_0404.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.

Enzyme and pathway databases

BioCycTARS426114-WGS:GSYJ-390-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD6CRB3_THIA3
AccessionPrimary (citable) accession number: D6CRB3
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)