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D6CRB3

- D6CRB3_THIA3

UniProt

D6CRB3 - D6CRB3_THIA3

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Protein

D-alanine--D-alanine ligase

Gene
ddlB, ddl, THI_0404
Organism
Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi264 – 2641Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi278 – 2781Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi278 – 2781Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi280 – 2801Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi137 – 19256ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciTARS426114-WGS:GSYJ-390-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlBImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:THI_0404Imported
OrganismiThiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)Imported
Taxonomic identifieri426114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesThiomonas
ProteomesiUP000002372: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD6CRB3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 311201ATP-grasp By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6CRB3-1 [UniParc]FASTAAdd to Basket

« Hide

MTPWPQIDPR GLGRVAVLMG GLSAEREVSL MSGKGVLAAL QSRGVDAFAF    50
DPSVDDLAAL KSFGAQRAFI NLHGRWGEDG TVQGALELLG IPYTGPGVLA 100
SALAIDKAMT KRLWHFENLS TPKWREVGTL IEARAAAAEL GFPLIFKATH 150
EGSTLGLKRA DSEAEVQAAY LEAARFDSRV LVEQFIEGDE VTCAVIGAGD 200
QARALPLIRI VAPGGNYDYE HKYFSDDTRY ICPSELPADE EARIQDLVLR 250
SYRTLGCRGW ARADVMIRAT DRQPFLLEIN TSPGMTSHSL VPMAARVAGL 300
EYADLCLLIL SMAALDQPHK GVDPQAAASP ALPPEEAIPT PALPTSGEGA 350
NTPPPRRGGG WEGEKPALGR PGGGRSDR 378
Length:378
Mass (Da):40,418
Last modified:July 13, 2010 - v1
Checksum:iA8415C11FACABEE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP475956 Genomic DNA. Translation: CAZ87154.1.
RefSeqiWP_013104536.1. NC_014145.1.
YP_003623017.1. NC_014145.1.

Genome annotation databases

EnsemblBacteriaiCAZ87154; CAZ87154; THI_0404.
GeneIDi13880247.
KEGGithi:THI_0404.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP475956 Genomic DNA. Translation: CAZ87154.1 .
RefSeqi WP_013104536.1. NC_014145.1.
YP_003623017.1. NC_014145.1.

3D structure databases

ProteinModelPortali D6CRB3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAZ87154 ; CAZ87154 ; THI_0404 .
GeneIDi 13880247.
KEGGi thi:THI_0404.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci TARS426114-WGS:GSYJ-390-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Genoscope - CEA
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3As.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22701 / CIP 110005 / 3As.

Entry informationi

Entry nameiD6CRB3_THIA3
AccessioniPrimary (citable) accession number: D6CRB3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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