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D6CKL8

- D6CKL8_THIA3

UniProt

D6CKL8 - D6CKL8_THIA3

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Protein

Alanine racemase

Gene

dadX

Organism
Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTARS426114-WGS:GSYJ-726-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:dadXImported
Ordered Locus Names:THI_0773Imported
OrganismiThiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)Imported
Taxonomic identifieri426114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesThiomonas
ProteomesiUP000002372: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD6CKL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6CKL8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRPISAVIH TAALSHNLLR VRQATPASKV WAVVKANAYG HGIARAYGAL
60 70 80 90 100
RTADGFALLD LTEAEKLRAL GWVGPILLLE GCFAPEDLAL CERLNLWHVV
110 120 130 140 150
HCREQIDWLA VHRGNRTHRV FLKMNTGMNR VGFSPEAYAA AWERLNALPQ
160 170 180 190 200
VGEITHMTHF ACADEAGGID EALARFARGV GHLPGERTLS NSAAALVHGA
210 220 230 240 250
DPRVASDWVR PGIALYGSSP TGLALDAAHW KLRPAMSLRS ELIDIQHIAA
260 270 280 290 300
GECVGYGARF TAPRPMRIGV VACGYADGYP RVAPNGTPIV VDGVRTQLVG
310 320 330 340 350
RVSMDMITVD LEPVFAAGNQ PMIGSPVLLW GQDAQAELSI DEVAAAAGTL
360
GYELMCALAA RVPVRVE
Length:367
Mass (Da):39,331
Last modified:July 13, 2010 - v1
Checksum:iD199E0FA28291FFF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP475956 Genomic DNA. Translation: CAZ87486.1.
RefSeqiWP_013104844.1. NC_014145.1.
YP_003623329.1. NC_014145.1.

Genome annotation databases

EnsemblBacteriaiCAZ87486; CAZ87486; THI_0773.
GeneIDi13880580.
KEGGithi:THI_0773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FP475956 Genomic DNA. Translation: CAZ87486.1 .
RefSeqi WP_013104844.1. NC_014145.1.
YP_003623329.1. NC_014145.1.

3D structure databases

ProteinModelPortali D6CKL8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAZ87486 ; CAZ87486 ; THI_0773 .
GeneIDi 13880580.
KEGGi thi:THI_0773.

Phylogenomic databases

HOGENOMi HOG000031446.
KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TARS426114-WGS:GSYJ-726-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Genoscope - CEA
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3As.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22701 / CIP 110005 / 3AsImported.

Entry informationi

Entry nameiD6CKL8_THIA3
AccessioniPrimary (citable) accession number: D6CKL8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3