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Protein

Conotoxin Cl6.5

Gene
N/A
Organism
Californiconus californicus (California cone) (Conus californicus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Cl6.5
OrganismiCaliforniconus californicus (California cone) (Conus californicus)
Taxonomic identifieri1736779 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeCaliforniconus

Organism-specific databases

ConoServeri4038. Cl6.5 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000041497923 – 50By similarityAdd BLAST28
PeptideiPRO_000041498053 – 80Conotoxin Cl6.5Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 70By similarity
Disulfide bondi60 ↔ 74By similarity
Disulfide bondi69 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiD6C4L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D6C4L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTCVLIVA VLVLTACQFT AAIDSRDGQD NPALRSTGGM QRKSQTQRLS
60 70 80
KKCIPDHHGC GLLHHSRYCC NGTCFFVCIP
Length:80
Mass (Da):8,766
Last modified:July 13, 2010 - v1
Checksum:i599A4D32BB4F1AF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ959154 Genomic DNA. Translation: ADB93124.1.

Similar proteinsi

Entry informationi

Entry nameiCM65_CONCL
AccessioniPrimary (citable) accession number: D6C4L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 13, 2010
Last modified: November 22, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families