ID   D6B2N8_9ACTN            Unreviewed;       928 AA.
AC   D6B2N8; A0A126Y3B5; A0A2M9SLS9;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   24-JAN-2024, entry version 75.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|ARBA:ARBA00022419, ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000256|ARBA:ARBA00012305, ECO:0000256|HAMAP-Rule:MF_00595};
GN   Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595,
GN   ECO:0000313|EMBL:GHI46237.1};
GN   ORFNames=C0Q92_11395 {ECO:0000313|EMBL:RZE24541.1}, ScoT_24110
GN   {ECO:0000313|EMBL:GHI46237.1};
OS   Streptomyces albidoflavus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=1886 {ECO:0000313|EMBL:GHI46237.1, ECO:0000313|Proteomes:UP001051844};
RN   [1] {ECO:0000313|EMBL:RZE24541.1, ECO:0000313|Proteomes:UP000292693}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100770 {ECO:0000313|EMBL:RZE24541.1,
RC   ECO:0000313|Proteomes:UP000292693};
RA   Li Y., Huang Y.;
RT   "Population genomics insights into the ecological differentiation and
RT   adaptive evolution in streptomycetes.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GHI46237.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NBRC 12854 {ECO:0000313|EMBL:GHI46237.1};
RA   Komaki H., Tamura T.;
RT   "Whole genome shotgun sequence of Streptomyces albidoflavus NBRC 12854.";
RL   Submitted (SEP-2022) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC       for the tricarboxylic acid cycle. {ECO:0000256|ARBA:ARBA00003670,
CC       ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC         phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC         Evidence={ECO:0000256|ARBA:ARBA00001071, ECO:0000256|HAMAP-
CC         Rule:MF_00595};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|HAMAP-
CC         Rule:MF_00595};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|ARBA:ARBA00008346, ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GHI46237.1}.
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DR   EMBL; BNDZ01000005; GHI46237.1; -; Genomic_DNA.
DR   EMBL; PKLL01000012; RZE24541.1; -; Genomic_DNA.
DR   KEGG; salb:XNR_2069; -.
DR   eggNOG; COG2352; Bacteria.
DR   Proteomes; UP000292693; Unassembled WGS sequence.
DR   Proteomes; UP001051844; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   Gene3D; 1.20.1440.90; Phosphoenolpyruvate/pyruvate domain; 1.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   PANTHER; PTHR30523:SF6; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|ARBA:ARBA00023300, ECO:0000256|HAMAP-
KW   Rule:MF_00595};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00595};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_00595};
KW   Pyruvate {ECO:0000313|EMBL:RZE24541.1}.
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        154
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT                   ECO:0000256|PROSITE-ProRule:PRU10111"
FT   ACT_SITE        586
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT                   ECO:0000256|PROSITE-ProRule:PRU10112"
SQ   SEQUENCE   928 AA;  102753 MW;  4CD7F3940BD18B45 CRC64;
     MSSADAQATT TSATGRPGPT ETPEPARTTS PELRADIRRL GDLLGEALVR QEGHELLDLV
     ERVRALTRTD GEAAAELLGG LELEIAAKLV RAFSTYFHLA NVTEQVHRGR ELRARRAEEG
     GLLARTADRL KDADPEHLRA TVQNLNVRPV FTAHPTEAAR RSVLGKLRRI AELLETPVIE
     ADRRRHDTRL AENIDLVWQT DELRVVRPEP ADEARNAVYY LDELHAGAVG DVLEDLTAEL
     ARVGFELPEN SRPLTFGTWI GGDRDGNPNV TPEVTWDVLI LQHEHGINDA LEVVDELRGF
     LSNSIRYTGA TEELLASLQA DLDHLPEISP RYKRLNAEEP YRLKATCVRQ KLENTKERLA
     QGTAHQPGRD YLGTAELLTD LTLIQDSLRE HRGGLFADGR MNRTIRTLAA FGLQLATMDV
     REHADAHHHA LGQLFDRLGE ESWRYADMPR DYRTRLLAKE LRSRRPLAPS PAPLDAAGEK
     TLNVFHTVRR ALAVFGPEVV ESYIISMCQG ADDVFAAAVL AREAGLIDLH AGWAKIGIVP
     LLETTDELRA ADVILDEMLA DPSYRLLVSL RGDVQEVMLG YSDSSKFGGI TTSQWEIHRA
     QRRLRDVAHR YGVRLRLFHG RGGTVGRGGG PSHDAILAQP WGTLEGEIKV TEQGEVISDK
     YLVPSLAREN LELTVAATLQ ASALHTAPRQ SVEALARWDA AMDTVSEAAH TAYRKLVEDP
     DLPSYFLAST PVDQLAELHL GSRPSRRPGS GVSLDGLRAI PWVFGWTQSR QIVPGWFGVG
     SGLKALREAG LDGVLSEMYE HWHFFRNFVS NVEMTLAKTD LRIARHYVDT LVPDELRHVF
     DLIEAEHALT VAEILRVTGG EELLDSNPVL QQTFAIRDAY LDPISYLQVS LLARQRAAAE
     RGEDPDPLLS RALLLTVNGV AAGLRNTG
//