D5XD47 (D5XD47_THEPJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370 HAMAP-Rule MF_00741
EC=6.3.3.1 RuleBase RU004370 HAMAP-Rule MF_00741

Alternative name(s):
AIR synthase HAMAP-Rule MF_00741
AIRS HAMAP-Rule MF_00741
Phosphoribosyl-aminoimidazole synthetase HAMAP-Rule MF_00741

Gene names

Name:	purM HAMAP-Rule MF_00741
Ordered Locus Names:	TherJR_0828

Organism

Thermincola potens (strain JR) [Complete proteome] [HAMAP] EMBL ADG81695.1

Taxonomic identifier

635013 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Thermincola › Thermincola potens

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 HAMAP-Rule MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741 RuleBase RU004371
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00741.
Sequence similarities	Belongs to the AIR synthase family. RuleBase RU004370 HAMAP-Rule MF_00741

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP-Rule MF_00741
Cellular component	Cytoplasm HAMAP-Rule MF_00741
Ligand	ATP-binding HAMAP-Rule MF_00741 Nucleotide-binding
Molecular function	Ligase RuleBase RU004370 HAMAP-Rule MF_00741 EMBL ADG81695.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D5XD47 [UniParc]. Last modified July 13, 2010. Version 1. Checksum: 58F802C44F01D652	FASTA	353	37,373
	10 20 30 40 50 60 MGGEGNGRKK GITYADAGVD ITAGNEAVEL MKAHVKRTFR PEVLTGIGGF GGLFALDAAK 70 80 90 100 110 120 YKNPVLVSGT DGVGTKLKIA FMTGRHDTIG IDAVAMCVND ILVQGAEPLF FLDYLAVGKL 130 140 150 160 170 180 VPEKVADIVK GIAEGCRQAG CALIGGETAE MPGFYAEDEY DVAGFVVGIV DREKIIDGHA 190 200 210 220 230 240 VQPGDKLVGL PSSGLHSNGF SLARKVLLEI GGFALHETPA PLTRPLGEEL LEPTRIYVKQ 250 260 270 280 290 300 VLPLLEKHRI KGMAHITGGG LTENIPRILP NNCKVVIDPS AWTVPPIFKL IQETGRVVDH 310 320 330 340 350 EMLRTFNMGI GLVIIAAPDE AEAVMQTLAA NGEKAVYIGE VVPGEAAVEY KGV

References

[1]

"Complete sequence of Thermincola sp. JR." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Woyke T. Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JR.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002028 Genomic DNA. Translation: ADG81695.1.
RefSeq	YP_003639596.1. NC_014152.1.
3D structure databases
ProteinModelPortal	D5XD47.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADG81695; ADG81695; TherJR_0828.
GeneID	9148500.
KEGG	tjr:TherJR_0828.
PATRIC	38273137. VBITheSp141296_0882.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000229091.
KO	K01933.
Enzyme and pathway databases
UniPathway	UPA00074; UER00129.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D5XD47_THEPJ

Accession

Primary (citable) accession number: D5XD47

Entry history

Integrated into UniProtKB/TrEMBL:	July 13, 2010
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)