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D5X9A5 (D5X9A5_THEPJ) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136
Gene names
Ordered Locus Names:TherJR_2164
OrganismThermincola potens (strain JR) [Complete proteome] [HAMAP] EMBL ADG83009.1
Taxonomic identifier635013 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Thermincola ›

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. RuleBase RU004136

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. RuleBase RU004136

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. RuleBase RU004136

Subcellular location

Cytoplasm By similarity RuleBase RU004136.

Sequence similarities

Belongs to the MurCDEF family.

Sequences

Sequence LengthMass (Da)Tools
D5X9A5 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 00233AF140602DFF

FASTA45849,737
        10         20         30         40         50         60 
MYKMTLGEIA GAIKARMVKG NVDRVYTQVC TDSRQIVPGS LFVALKGERF DAHDFVEQAL 

        70         80         90        100        110        120 
QLGAHGVIVS RMQHDLPDGD ILLVDDTLTA LQQLARYNRK KFSGPVVAVT GSNGKTTTKD 

       130        140        150        160        170        180 
MISALLETKY LVLKTLGNFN NEIGLPLTLL GLDESHGAVV VEMGMRGLGE IDFLARIACP 

       190        200        210        220        230        240 
TAGVITNIGE THLERLGTVE NIARAKTELL PHIPVGGYAV LNGDDPWQRK YAHLTRAKVI 

       250        260        270        280        290        300 
FYGMDHSNHV YADNIKCNMG AGASFTVIRD KIAKVFHLPV PGRHNIYNAL AAITVGLQEG 

       310        320        330        340        350        360 
LSWEMCMEGL QNVVLSGMRL QIIDCNGLKI INDTYNANPA SSKAAVRILA EMPCAGKKVA 

       370        380        390        400        410        420 
VLGDMYELGQ RTVQGHREVG ETVQNLKIDI LVTVGELALH IAEAAKAAGM DRKNIYVSRN 

       430        440        450 
NNEALEILNN ILKAGDLVLV KGSRGMKMEK IVEGITCA

« Hide

References

[1]"Complete sequence of Thermincola sp. JR."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Woyke T.
Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002028 Genomic DNA. Translation: ADG83009.1.
RefSeqYP_003640910.1. NC_014152.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG83009; ADG83009; TherJR_2164.
GeneID9149859.
KEGGtjr:TherJR_2164.
PATRIC38276075. VBITheSp141296_2329.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000268120.
KOK01929.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD5X9A5_THEPJ
AccessionPrimary (citable) accession number: D5X9A5
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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