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Protein

Isocitrate dehydrogenase [NADP]

Gene

Tint_1393

Organism
Thiomonas intermedia (strain K12) (Thiobacillus intermedius)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTINT75379:GH6C-1410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Tint_1393Imported
OrganismiThiomonas intermedia (strain K12) (Thiobacillus intermedius)Imported
Taxonomic identifieri75379 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesThiomonas
ProteomesiUP000002185: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD5X0Y4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5X0Y4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQHIRVPAG EKITVNPDFS LNVPDHPIIP YIEGDGTGFD ITPVMTKVVD
60 70 80 90 100
AAVEKAYGGK RKIAWMEIFA GEKATRVYGP DVWLPEITLQ ILRDYVVSIK
110 120 130 140 150
GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYFQGVPSP VKHPEKTDMV
160 170 180 190 200
IFRENSEDIY AGIEWAAESE GAKKLVNFLI NEMGVKKIRF PDTSGIGIKP
210 220 230 240 250
VSREGTERLV RKALQYAIDN DRKSVTLVHK GNIMKFTEGA FRDWGYGLAS
260 270 280 290 300
KEFGAQLLDG GPWMRFKNPK TGREIVVKDM IADAFLQQIL LRPDEYDVIA
310 320 330 340 350
TLNLNGDYVS DALAAQVGGI GIAPGANLSD SVAMFEATHG TAPKYAGKDY
360 370 380 390 400
VNPGSEILSA EMMLRHMGWV EAADRIIASM EKSILSKQVT YDFARLLPDA
410
TQVSCSGFGQ VMIDHM
Length:416
Mass (Da):45,883
Last modified:July 13, 2010 - v1
Checksum:i237F6E5BF8AC5893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002021 Genomic DNA. Translation: ADG30780.1.
RefSeqiWP_013123053.1. NC_014153.1.
YP_003643110.1. NC_014153.1.

Genome annotation databases

EnsemblBacteriaiADG30780; ADG30780; Tint_1393.
GeneIDi9152124.
KEGGitin:Tint_1393.
PATRICi38293314. VBIThiInt85915_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002021 Genomic DNA. Translation: ADG30780.1.
RefSeqiWP_013123053.1. NC_014153.1.
YP_003643110.1. NC_014153.1.

3D structure databases

ProteinModelPortaliD5X0Y4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG30780; ADG30780; Tint_1393.
GeneIDi9152124.
KEGGitin:Tint_1393.
PATRICi38293314. VBIThiInt85915_1417.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.

Enzyme and pathway databases

BioCyciTINT75379:GH6C-1410-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12Imported.

Entry informationi

Entry nameiD5X0Y4_THIK1
AccessioniPrimary (citable) accession number: D5X0Y4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.