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D5X0Y4

- D5X0Y4_THIK1

UniProt

D5X0Y4 - D5X0Y4_THIK1

Protein

Isocitrate dehydrogenase [NADP]

Gene

Tint_1393

Organism
Thiomonas intermedia (strain K12) (Thiobacillus intermedius)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciTINT75379:GH6C-1410-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Tint_1393Imported
    OrganismiThiomonas intermedia (strain K12) (Thiobacillus intermedius)Imported
    Taxonomic identifieri75379 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesThiomonas
    ProteomesiUP000002185: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD5X0Y4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5X0Y4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQHIRVPAG EKITVNPDFS LNVPDHPIIP YIEGDGTGFD ITPVMTKVVD    50
    AAVEKAYGGK RKIAWMEIFA GEKATRVYGP DVWLPEITLQ ILRDYVVSIK 100
    GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYFQGVPSP VKHPEKTDMV 150
    IFRENSEDIY AGIEWAAESE GAKKLVNFLI NEMGVKKIRF PDTSGIGIKP 200
    VSREGTERLV RKALQYAIDN DRKSVTLVHK GNIMKFTEGA FRDWGYGLAS 250
    KEFGAQLLDG GPWMRFKNPK TGREIVVKDM IADAFLQQIL LRPDEYDVIA 300
    TLNLNGDYVS DALAAQVGGI GIAPGANLSD SVAMFEATHG TAPKYAGKDY 350
    VNPGSEILSA EMMLRHMGWV EAADRIIASM EKSILSKQVT YDFARLLPDA 400
    TQVSCSGFGQ VMIDHM 416
    Length:416
    Mass (Da):45,883
    Last modified:July 13, 2010 - v1
    Checksum:i237F6E5BF8AC5893
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002021 Genomic DNA. Translation: ADG30780.1.
    RefSeqiYP_003643110.1. NC_014153.1.

    Genome annotation databases

    EnsemblBacteriaiADG30780; ADG30780; Tint_1393.
    GeneIDi9152124.
    KEGGitin:Tint_1393.
    PATRICi38293314. VBIThiInt85915_1417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002021 Genomic DNA. Translation: ADG30780.1 .
    RefSeqi YP_003643110.1. NC_014153.1.

    3D structure databases

    ProteinModelPortali D5X0Y4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG30780 ; ADG30780 ; Tint_1393 .
    GeneIDi 9152124.
    KEGGi tin:Tint_1393.
    PATRICi 38293314. VBIThiInt85915_1417.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.

    Enzyme and pathway databases

    BioCyci TINT75379:GH6C-1410-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12Imported.

    Entry informationi

    Entry nameiD5X0Y4_THIK1
    AccessioniPrimary (citable) accession number: D5X0Y4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3