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D5WWS8 (D5WWS8_KYRT2) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Btus_1041 EMBL ADG05779.1
OrganismKyrpidia tusciae (strain DSM 2912 / NBRC 15312 / T2) (Bacillus tusciae) [Complete proteome] [HAMAP] EMBL ADG05779.1
Taxonomic identifier562970 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesAlicyclobacillaceaeKyrpidia

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain150 – 358209ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding183 – 23856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3161Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3291Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3291Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3311Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D5WWS8 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: A7FB527CE84D60AA

FASTA39743,935
        10         20         30         40         50         60 
MKKLIAVIFG GRSVEHEVSI VTAQQIMYQL RRDLYDVMPL YIDKEGAWWT GDVLAKLESF 

        70         80         90        100        110        120 
KAANRNAALA QAARVIVVPT PGGGVIEDPQ ALRGLFRKPR RWTPDVAILA THGTYGEDGC 

       130        140        150        160        170        180 
LQGLLEIAGI PYTGPGVLGS AVGMDKILMK DVFRAQGIPV VNYIWIHRDE WHEHPDEVAD 

       190        200        210        220        230        240 
RVERELQYPV FVKPSNLGSS VGIGRAEDRD GLFHAMDVAA GYDRRLLIEQ GVVSPREINC 

       250        260        270        280        290        300 
SVLADGQDLR VSLCEEPVSW EAFLSYEDKY IRGNFTKGQT GRRIPADLPD GVTEAVQELA 

       310        320        330        340        350        360 
RRAFRAIQAR GVARVDFLLS PDGSIYVNEI NTIPGSLSFY LWEPSGVSFP DLLDKLIEDA 

       370        380        390 
LADYRDKSRN ISTYDTDLIE QFGRGGKVGS KASPQTS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002017 Genomic DNA. Translation: ADG05779.1.
RefSeqYP_003588923.1. NC_014098.1.

3D structure databases

ProteinModelPortalD5WWS8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG05779; ADG05779; Btus_1041.
GeneID9108968.
KEGGbts:Btus_1041.
PATRIC37245086. VBIBacTus29608_1092.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.

Enzyme and pathway databases

BioCycKTUS562970:GHUX-1063-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5WWS8_KYRT2
AccessionPrimary (citable) accession number: D5WWS8
Entry history
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)