Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homoserine kinase

Gene

thrB

Organism
Burkholderia sp. (strain CCGE1002)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. homoserine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP640511:GJ7J-5341-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotationSAAS annotation (EC:2.7.1.39UniRule annotationSAAS annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:BC1002_5260Imported
OrganismiBurkholderia sp. (strain CCGE1002)Imported
Taxonomic identifieri640511 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000002190: Chromosome 2

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudomonas-type ThrB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004810.
KOiK02204.

Family and domain databases

HAMAPiMF_00301. Homoser_kinase_2.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.

Sequencei

Sequence statusi: Complete.

D5WES3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVFTAVNES QLAEWMSHYD LGDVVEFRGI SSGIENSNFF LTTTRGEYVL
60 70 80 90 100
TIFEKLTAEQ LPFYLDLMRH LAAHRVPVPD PMPRLDGALF GMLLGKPATI
110 120 130 140 150
VTKLEGAPEL APGVEHCAEV GHMLARMHLA GRDYPRYQPN LRSLPWWRET
160 170 180 190 200
VPTILPYLEG EQRDLLASEL AHQEAFFASA DYAAMPSGPC HADLFRDNAM
210 220 230 240 250
FAHAAPETGH EVRLGGFFDF YFAGCDKWLF DVAVTVNDWC VDLATGKLDT
260 270 280 290 300
ERTEALLRAY QTVRPFTVEE NHHWGDMLRA GAYRFWVSRL YDFHLPRAAE
310 320 330
LLKPHDPGHF ERILRERLLG VANPGIHTPC N
Length:331
Mass (Da):37,469
Last modified:July 13, 2010 - v1
Checksum:iB4164659358E14DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002014 Genomic DNA. Translation: ADG19198.1.
RefSeqiYP_003608709.1. NC_014118.1.

Genome annotation databases

EnsemblBacteriaiADG19198; ADG19198; BC1002_5260.
GeneIDi9114575.
KEGGibge:BC1002_5260.
PATRICi37219602. VBIBurSp41388_5343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002014 Genomic DNA. Translation: ADG19198.1.
RefSeqiYP_003608709.1. NC_014118.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG19198; ADG19198; BC1002_5260.
GeneIDi9114575.
KEGGibge:BC1002_5260.
PATRICi37219602. VBIBurSp41388_5343.

Phylogenomic databases

HOGENOMiHOG000004810.
KOiK02204.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.
BioCyciBSP640511:GJ7J-5341-MONOMER.

Family and domain databases

HAMAPiMF_00301. Homoser_kinase_2.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 2 of Burkholderia sp. CCGE1002."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Martinez-Romero E., Hernandez M.A.R., Tiedje J.M., Woyke T.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCGE1002Imported.

Entry informationi

Entry nameiD5WES3_BURSC
AccessioniPrimary (citable) accession number: D5WES3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.