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Protein

Homoserine kinase

Gene

thrB

Organism
Burkholderia sp. (strain CCGE1002)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (BC1002_1819)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (BC1002_1378)
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSP640511:G1GLK-5290-MONOMER
UniPathwayiUPA00050; UER00064

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotationSAAS annotation (EC:2.7.1.39UniRule annotationSAAS annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:BC1002_5260Imported
OrganismiBurkholderia sp. (strain CCGE1002)Imported
Taxonomic identifieri640511 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
Proteomesi
  • UP000002190 Componenti: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi640511.BC1002_5260

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 261APHInterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the pseudomonas-type ThrB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CUV Bacteria
COG2334 LUCA
HOGENOMiHOG000004810
KOiK02204
OMAiAGALRFW
OrthoDBiPOG091H0G0T

Family and domain databases

CDDicd05153 HomoserineK_II, 1 hit
HAMAPiMF_00301 Homoser_kinase_2, 1 hit
InterProiView protein in InterPro
IPR002575 Aminoglycoside_PTrfase
IPR005280 Homoserine_kinase_II
IPR011009 Kinase-like_dom_sf
PfamiView protein in Pfam
PF01636 APH, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR00938 thrB_alt, 1 hit

Sequencei

Sequence statusi: Complete.

D5WES3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFTAVNES QLAEWMSHYD LGDVVEFRGI SSGIENSNFF LTTTRGEYVL
60 70 80 90 100
TIFEKLTAEQ LPFYLDLMRH LAAHRVPVPD PMPRLDGALF GMLLGKPATI
110 120 130 140 150
VTKLEGAPEL APGVEHCAEV GHMLARMHLA GRDYPRYQPN LRSLPWWRET
160 170 180 190 200
VPTILPYLEG EQRDLLASEL AHQEAFFASA DYAAMPSGPC HADLFRDNAM
210 220 230 240 250
FAHAAPETGH EVRLGGFFDF YFAGCDKWLF DVAVTVNDWC VDLATGKLDT
260 270 280 290 300
ERTEALLRAY QTVRPFTVEE NHHWGDMLRA GAYRFWVSRL YDFHLPRAAE
310 320 330
LLKPHDPGHF ERILRERLLG VANPGIHTPC N
Length:331
Mass (Da):37,469
Last modified:July 13, 2010 - v1
Checksum:iB4164659358E14DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002014 Genomic DNA Translation: ADG19198.1
RefSeqiWP_013092990.1, NC_014118.1

Genome annotation databases

EnsemblBacteriaiADG19198; ADG19198; BC1002_5260
KEGGibge:BC1002_5260

Similar proteinsi

Entry informationi

Entry nameiD5WES3_BURSC
AccessioniPrimary (citable) accession number: D5WES3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 25, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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