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D5W8D6

- D5W8D6_BURSC

UniProt

D5W8D6 - D5W8D6_BURSC

Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Burkholderia sp. (strain CCGE1002)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Involved in phosphonate degradation.UniRule annotation

    Catalytic activityi

    Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101NucleophileUniRule annotation
    Metal bindingi10 – 101MagnesiumUniRule annotation
    Metal bindingi12 – 121Magnesium; via carbonyl oxygenUniRule annotation
    Active sitei51 – 511Schiff-base intermediate with substrateUniRule annotation
    Metal bindingi184 – 1841MagnesiumUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. organic phosphonate catabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Schiff baseUniRule annotation

    Enzyme and pathway databases

    BioCyciBSP640511:GJ7J-1636-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
    Short name:
    PhosphonataseUniRule annotation
    Alternative name(s):
    Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
    Gene namesi
    Name:phnXUniRule annotation
    Ordered Locus Names:BC1002_1612Imported
    OrganismiBurkholderia sp. (strain CCGE1002)Imported
    Taxonomic identifieri640511 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000002190: Chromosome 1

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5W8D6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000217971.
    KOiK05306.

    Family and domain databases

    Gene3Di1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPiMF_01375. PhnX.
    InterProiIPR023214. HAD-like_dom.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view]
    PfamiPF13419. HAD_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01422. phosphonatase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D5W8D6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYVKAVIFD WAGTVVDYGS RAPMGAFVET FEQFGVPITI DEARGPMGMA    50
    KRPHIAALMA LPRVAQAWAE RHGHTPTDAD IDAVYDVFVP KNIAVAASYS 100
    AVIPGVAEVA SALRHDDIRI GTTTGYTREI IDEIVPGAAA QGFSPDSIVC 150
    TGDTPEGRPS PYMIYRTLPQ LGVWRAKEAI KVDDTEVGIE EGINGGTWTV 200
    GVAVSGNAFG MSEAEVKALP ADEFAARRNV ATARLKAAGA HYVIDSVADL 250
    MPVVYDIDAR LARGERP 267
    Length:267
    Mass (Da):28,516
    Last modified:July 13, 2010 - v1
    Checksum:iDE63A3E26CA1B2DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002013 Genomic DNA. Translation: ADG15681.1.
    RefSeqiYP_003605192.1. NC_014117.1.

    Genome annotation databases

    EnsemblBacteriaiADG15681; ADG15681; BC1002_1612.
    GeneIDi9089297.
    KEGGibge:BC1002_1612.
    PATRICi37212064. VBIBurSp41388_1631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002013 Genomic DNA. Translation: ADG15681.1 .
    RefSeqi YP_003605192.1. NC_014117.1.

    3D structure databases

    ProteinModelPortali D5W8D6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG15681 ; ADG15681 ; BC1002_1612 .
    GeneIDi 9089297.
    KEGGi bge:BC1002_1612.
    PATRICi 37212064. VBIBurSp41388_1631.

    Phylogenomic databases

    HOGENOMi HOG000217971.
    KOi K05306.

    Enzyme and pathway databases

    BioCyci BSP640511:GJ7J-1636-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPi MF_01375. PhnX.
    InterProi IPR023214. HAD-like_dom.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view ]
    Pfami PF13419. HAD_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01422. phosphonatase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia sp. CCGE1002."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Martinez-Romero E., Hernandez M.A.R., Tiedje J.M., Woyke T.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCGE1002Imported.

    Entry informationi

    Entry nameiD5W8D6_BURSC
    AccessioniPrimary (citable) accession number: D5W8D6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3